Coordinating cell polarization and morphogenesis through mechanical feedback.
Many cellular processes require cell polarization to be maintained as the cell changes shape, grows or moves. Without feedback mechanisms relaying information about cell shape to the polarity molecular machinery, the coordination between cell polarization and morphogenesis, movement or growth would...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://doi.org/10.1371/journal.pcbi.1007971 |
| _version_ | 1818735595231379456 |
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| author | Samhita P Banavar Michael Trogdon Brian Drawert Tau-Mu Yi Linda R Petzold Otger Campàs |
| author_facet | Samhita P Banavar Michael Trogdon Brian Drawert Tau-Mu Yi Linda R Petzold Otger Campàs |
| author_sort | Samhita P Banavar |
| collection | DOAJ |
| description | Many cellular processes require cell polarization to be maintained as the cell changes shape, grows or moves. Without feedback mechanisms relaying information about cell shape to the polarity molecular machinery, the coordination between cell polarization and morphogenesis, movement or growth would not be possible. Here we theoretically and computationally study the role of a genetically-encoded mechanical feedback (in the Cell Wall Integrity pathway) as a potential coordination mechanism between cell morphogenesis and polarity during budding yeast mating projection growth. We developed a coarse-grained continuum description of the coupled dynamics of cell polarization and morphogenesis as well as 3D stochastic simulations of the molecular polarization machinery in the evolving cell shape. Both theoretical approaches show that in the absence of mechanical feedback (or in the presence of weak feedback), cell polarity cannot be maintained at the projection tip during growth, with the polarization cap wandering off the projection tip, arresting morphogenesis. In contrast, for mechanical feedback strengths above a threshold, cells can robustly maintain cell polarization at the tip and simultaneously sustain mating projection growth. These results indicate that the mechanical feedback encoded in the Cell Wall Integrity pathway can provide important positional information to the molecular machinery in the cell, thereby enabling the coordination of cell polarization and morphogenesis. |
| first_indexed | 2024-12-18T00:23:45Z |
| format | Article |
| id | doaj.art-e34c6226ee824aeba51118c8455e5433 |
| institution | Directory Open Access Journal |
| issn | 1553-734X 1553-7358 |
| language | English |
| last_indexed | 2024-12-18T00:23:45Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj.art-e34c6226ee824aeba51118c8455e54332022-12-21T21:27:17ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582021-01-01171e100797110.1371/journal.pcbi.1007971Coordinating cell polarization and morphogenesis through mechanical feedback.Samhita P BanavarMichael TrogdonBrian DrawertTau-Mu YiLinda R PetzoldOtger CampàsMany cellular processes require cell polarization to be maintained as the cell changes shape, grows or moves. Without feedback mechanisms relaying information about cell shape to the polarity molecular machinery, the coordination between cell polarization and morphogenesis, movement or growth would not be possible. Here we theoretically and computationally study the role of a genetically-encoded mechanical feedback (in the Cell Wall Integrity pathway) as a potential coordination mechanism between cell morphogenesis and polarity during budding yeast mating projection growth. We developed a coarse-grained continuum description of the coupled dynamics of cell polarization and morphogenesis as well as 3D stochastic simulations of the molecular polarization machinery in the evolving cell shape. Both theoretical approaches show that in the absence of mechanical feedback (or in the presence of weak feedback), cell polarity cannot be maintained at the projection tip during growth, with the polarization cap wandering off the projection tip, arresting morphogenesis. In contrast, for mechanical feedback strengths above a threshold, cells can robustly maintain cell polarization at the tip and simultaneously sustain mating projection growth. These results indicate that the mechanical feedback encoded in the Cell Wall Integrity pathway can provide important positional information to the molecular machinery in the cell, thereby enabling the coordination of cell polarization and morphogenesis.https://doi.org/10.1371/journal.pcbi.1007971 |
| spellingShingle | Samhita P Banavar Michael Trogdon Brian Drawert Tau-Mu Yi Linda R Petzold Otger Campàs Coordinating cell polarization and morphogenesis through mechanical feedback. PLoS Computational Biology |
| title | Coordinating cell polarization and morphogenesis through mechanical feedback. |
| title_full | Coordinating cell polarization and morphogenesis through mechanical feedback. |
| title_fullStr | Coordinating cell polarization and morphogenesis through mechanical feedback. |
| title_full_unstemmed | Coordinating cell polarization and morphogenesis through mechanical feedback. |
| title_short | Coordinating cell polarization and morphogenesis through mechanical feedback. |
| title_sort | coordinating cell polarization and morphogenesis through mechanical feedback |
| url | https://doi.org/10.1371/journal.pcbi.1007971 |
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