Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice
GPRASP2 plays a role in trafficking of GPCRs and mutations in this gene have been linked to neurodevelopmental disorders. Here the authors study the role of Gprasp2 in the CNS and show that it regulates the surface availability of mGluR5 receptors and that knockout mice for this protein show autisti...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2019-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09382-9 |
| _version_ | 1818342665393012736 |
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| author | Mohamed Edfawy Joana R. Guedes Marta I. Pereira Mariana Laranjo Mário J. Carvalho Xian Gao Pedro A. Ferreira Gladys Caldeira Lara O. Franco Dongqing Wang Ana Luisa Cardoso Guoping Feng Ana Luisa Carvalho João Peça |
| author_facet | Mohamed Edfawy Joana R. Guedes Marta I. Pereira Mariana Laranjo Mário J. Carvalho Xian Gao Pedro A. Ferreira Gladys Caldeira Lara O. Franco Dongqing Wang Ana Luisa Cardoso Guoping Feng Ana Luisa Carvalho João Peça |
| author_sort | Mohamed Edfawy |
| collection | DOAJ |
| description | GPRASP2 plays a role in trafficking of GPCRs and mutations in this gene have been linked to neurodevelopmental disorders. Here the authors study the role of Gprasp2 in the CNS and show that it regulates the surface availability of mGluR5 receptors and that knockout mice for this protein show autistic-like behavioural abnormalities. |
| first_indexed | 2024-12-13T16:18:18Z |
| format | Article |
| id | doaj.art-e34c7220e13b45b1be4e855d23adeb92 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-13T16:18:18Z |
| publishDate | 2019-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e34c7220e13b45b1be4e855d23adeb922022-12-21T23:38:47ZengNature PortfolioNature Communications2041-17232019-03-0110111510.1038/s41467-019-09382-9Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant miceMohamed Edfawy0Joana R. Guedes1Marta I. Pereira2Mariana Laranjo3Mário J. Carvalho4Xian Gao5Pedro A. Ferreira6Gladys Caldeira7Lara O. Franco8Dongqing Wang9Ana Luisa Cardoso10Guoping Feng11Ana Luisa Carvalho12João Peça13CNC - Center for Neuroscience and Cell Biology, University of CoimbraCNC - Center for Neuroscience and Cell Biology, University of CoimbraCNC - Center for Neuroscience and Cell Biology, University of CoimbraCNC - Center for Neuroscience and Cell Biology, University of CoimbraCNC - Center for Neuroscience and Cell Biology, University of CoimbraMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of TechnologyCNC - Center for Neuroscience and Cell Biology, University of CoimbraCNC - Center for Neuroscience and Cell Biology, University of CoimbraCNC - Center for Neuroscience and Cell Biology, University of CoimbraMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of TechnologyCNC - Center for Neuroscience and Cell Biology, University of CoimbraMcGovern Institute for Brain Research, Department of Brain and Cognitive Sciences, Massachusetts Institute of TechnologyCNC - Center for Neuroscience and Cell Biology, University of CoimbraCNC - Center for Neuroscience and Cell Biology, University of CoimbraGPRASP2 plays a role in trafficking of GPCRs and mutations in this gene have been linked to neurodevelopmental disorders. Here the authors study the role of Gprasp2 in the CNS and show that it regulates the surface availability of mGluR5 receptors and that knockout mice for this protein show autistic-like behavioural abnormalities.https://doi.org/10.1038/s41467-019-09382-9 |
| spellingShingle | Mohamed Edfawy Joana R. Guedes Marta I. Pereira Mariana Laranjo Mário J. Carvalho Xian Gao Pedro A. Ferreira Gladys Caldeira Lara O. Franco Dongqing Wang Ana Luisa Cardoso Guoping Feng Ana Luisa Carvalho João Peça Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice Nature Communications |
| title | Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice |
| title_full | Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice |
| title_fullStr | Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice |
| title_full_unstemmed | Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice |
| title_short | Abnormal mGluR-mediated synaptic plasticity and autism-like behaviours in Gprasp2 mutant mice |
| title_sort | abnormal mglur mediated synaptic plasticity and autism like behaviours in gprasp2 mutant mice |
| url | https://doi.org/10.1038/s41467-019-09382-9 |
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