The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity
BackgroundChildhood obesity has increased worldwide, becoming a significant public health concern. Brain-derived neurotrophic factor (BDNF) plays an important role in the central regulation of food intake and body weight, but little is known regarding its role in childhood obesity. Next to obesity,...
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Frontiers Media S.A.
2022-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2021.835515/full |
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| author | Sanae Makhout Eline Vermeiren Karolien Van De Maele Karolien Van De Maele Luc Bruyndonckx Luc Bruyndonckx Luc Bruyndonckx Benedicte Y. De Winter Benedicte Y. De Winter Kim Van Hoorenbeeck Kim Van Hoorenbeeck Stijn L. Verhulst Stijn L. Verhulst Annelies Van Eyck Annelies Van Eyck |
| author_facet | Sanae Makhout Eline Vermeiren Karolien Van De Maele Karolien Van De Maele Luc Bruyndonckx Luc Bruyndonckx Luc Bruyndonckx Benedicte Y. De Winter Benedicte Y. De Winter Kim Van Hoorenbeeck Kim Van Hoorenbeeck Stijn L. Verhulst Stijn L. Verhulst Annelies Van Eyck Annelies Van Eyck |
| author_sort | Sanae Makhout |
| collection | DOAJ |
| description | BackgroundChildhood obesity has increased worldwide, becoming a significant public health concern. Brain-derived neurotrophic factor (BDNF) plays an important role in the central regulation of food intake and body weight, but little is known regarding its role in childhood obesity. Next to obesity, BDNF has been linked to obstructive sleep apnea (OSA) and endothelial dysfunction, two obesity-related comorbidities. The aim of this study is to investigate how BDNF, OSA and endothelial dysfunction interact in children with obesity and to determine the effect of weight loss on serum BDNF levels.MethodsChildren and adolescents with obesity aged 8–18 years who were enrolled in a multidisciplinary obesity treatment (MOT) in a tertiary hospital, were prospectively included. Several examinations were conducted during this MOT; at baseline, after 6 months and after 12 months, including the assessment of endothelial function, body composition measurements and a polysomnography. BDNF levels were measured on a serum sample by means of ELISA.ResultsA total of 103 patients with obesity was included, of which 20 had OSA (19.4%). BDNF levels were comparable in children with obesity and OSA and children with obesity but without OSA (26.75 vs. 27.87 ng/ml, p = 0.6). No correlations were found between BDNF and sleep-related variables or between BDNF and endothelial function parameters nor between BDNF and adiposity measures. To investigate if the interaction between OSA and endothelial dysfunction had an influence on BDNF levels, a general linear model was used. This model revealed that a diagnosis of OSA, as well as the interaction between OSA and maximal endothelial dilatation, contributed significantly (p = 0.03, p = 0.04, respectively) to BDNF levels. After 1 year of weight loss therapy, BDNF levels did not change (26.18 vs. 25.46 ng/ml, p = 0.7) in our population.ConclusionBDNF concentrations were comparable in children with obesity, both with and without OSA, indicating that BDNF levels are not affected by OSA. However, we did find an interaction effect of OSA and endothelial function on BDNF levels. |
| first_indexed | 2024-12-18T02:45:21Z |
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| language | English |
| last_indexed | 2024-12-18T02:45:21Z |
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| series | Frontiers in Medicine |
| spelling | doaj.art-e34f6526760e4848b835d5657a0ce8f52022-12-21T21:23:34ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-01-01810.3389/fmed.2021.835515835515The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With ObesitySanae Makhout0Eline Vermeiren1Karolien Van De Maele2Karolien Van De Maele3Luc Bruyndonckx4Luc Bruyndonckx5Luc Bruyndonckx6Benedicte Y. De Winter7Benedicte Y. De Winter8Kim Van Hoorenbeeck9Kim Van Hoorenbeeck10Stijn L. Verhulst11Stijn L. Verhulst12Annelies Van Eyck13Annelies Van Eyck14Laboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, BelgiumLaboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, BelgiumLaboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, BelgiumDepartment of Pediatrics, Antwerp University Hospital, Edegem, BelgiumLaboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, BelgiumDepartment of Pediatrics, Antwerp University Hospital, Edegem, BelgiumDepartment of Pediatric Cardiology, Amsterdam University Medical Centers, Amsterdam, NetherlandsLaboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, BelgiumDepartment of Gastroenterology and Hepatology, Antwerp University Hospital, Edegem, BelgiumLaboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, BelgiumDepartment of Pediatrics, Antwerp University Hospital, Edegem, BelgiumLaboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, BelgiumDepartment of Pediatrics, Antwerp University Hospital, Edegem, BelgiumLaboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, BelgiumDepartment of Pediatrics, Antwerp University Hospital, Edegem, BelgiumBackgroundChildhood obesity has increased worldwide, becoming a significant public health concern. Brain-derived neurotrophic factor (BDNF) plays an important role in the central regulation of food intake and body weight, but little is known regarding its role in childhood obesity. Next to obesity, BDNF has been linked to obstructive sleep apnea (OSA) and endothelial dysfunction, two obesity-related comorbidities. The aim of this study is to investigate how BDNF, OSA and endothelial dysfunction interact in children with obesity and to determine the effect of weight loss on serum BDNF levels.MethodsChildren and adolescents with obesity aged 8–18 years who were enrolled in a multidisciplinary obesity treatment (MOT) in a tertiary hospital, were prospectively included. Several examinations were conducted during this MOT; at baseline, after 6 months and after 12 months, including the assessment of endothelial function, body composition measurements and a polysomnography. BDNF levels were measured on a serum sample by means of ELISA.ResultsA total of 103 patients with obesity was included, of which 20 had OSA (19.4%). BDNF levels were comparable in children with obesity and OSA and children with obesity but without OSA (26.75 vs. 27.87 ng/ml, p = 0.6). No correlations were found between BDNF and sleep-related variables or between BDNF and endothelial function parameters nor between BDNF and adiposity measures. To investigate if the interaction between OSA and endothelial dysfunction had an influence on BDNF levels, a general linear model was used. This model revealed that a diagnosis of OSA, as well as the interaction between OSA and maximal endothelial dilatation, contributed significantly (p = 0.03, p = 0.04, respectively) to BDNF levels. After 1 year of weight loss therapy, BDNF levels did not change (26.18 vs. 25.46 ng/ml, p = 0.7) in our population.ConclusionBDNF concentrations were comparable in children with obesity, both with and without OSA, indicating that BDNF levels are not affected by OSA. However, we did find an interaction effect of OSA and endothelial function on BDNF levels.https://www.frontiersin.org/articles/10.3389/fmed.2021.835515/fullbrain-derived neurotrophic factorpediatric obesityobstructive sleep apneaendothelial functionweight loss treatmentmultidisciplinary obesity treatment |
| spellingShingle | Sanae Makhout Eline Vermeiren Karolien Van De Maele Karolien Van De Maele Luc Bruyndonckx Luc Bruyndonckx Luc Bruyndonckx Benedicte Y. De Winter Benedicte Y. De Winter Kim Van Hoorenbeeck Kim Van Hoorenbeeck Stijn L. Verhulst Stijn L. Verhulst Annelies Van Eyck Annelies Van Eyck The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity Frontiers in Medicine brain-derived neurotrophic factor pediatric obesity obstructive sleep apnea endothelial function weight loss treatment multidisciplinary obesity treatment |
| title | The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity |
| title_full | The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity |
| title_fullStr | The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity |
| title_full_unstemmed | The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity |
| title_short | The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity |
| title_sort | role of brain derived neurotrophic factor in obstructive sleep apnea and endothelial function in a pediatric population with obesity |
| topic | brain-derived neurotrophic factor pediatric obesity obstructive sleep apnea endothelial function weight loss treatment multidisciplinary obesity treatment |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2021.835515/full |
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