Differences in social interaction- vs cocaine reward in rat vs mouse
We previously developed rat experimental models based on the conditioned place preference (CPP) paradigm in which only four 15-min episodes of dyadic social interaction with a sex- and weight-matched male Sprague Dawley rat (1) reversed CPP from cocaine to social interaction despite continuing cocai...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-10-01
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| Series: | Frontiers in Behavioral Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00363/full |
| _version_ | 1811277532653158400 |
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| author | Kai K Kummer Lena eHofhansel Constanze M Barwitz Aurelia eSchardl Janine Maria Prast Ahmad eSalti Rana eEl Rawas Gerald eZernig Gerald eZernig |
| author_facet | Kai K Kummer Lena eHofhansel Constanze M Barwitz Aurelia eSchardl Janine Maria Prast Ahmad eSalti Rana eEl Rawas Gerald eZernig Gerald eZernig |
| author_sort | Kai K Kummer |
| collection | DOAJ |
| description | We previously developed rat experimental models based on the conditioned place preference (CPP) paradigm in which only four 15-min episodes of dyadic social interaction with a sex- and weight-matched male Sprague Dawley rat (1) reversed CPP from cocaine to social interaction despite continuing cocaine training, and (2) prevented the reacquisition/re-expression of cocaine CPP. In a concurrent conditioning schedule, pairing one compartment with social interaction and the other compartment with 15 mg/kg cocaine injections, rats spent the same amount of time in both compartments and the most rewarding sensory component of the composite stimulus social interaction was touch (taction). In the present study, we validated our experimental paradigm in C57BL/6 mice to investigate if our experimental paradigm may be useful for the considerable number of genetically modified mouse models. Only 71% of the tested mice developed place preference for social interaction, whereas 85% of the rats did. Accordingly, 29% of the mice developed conditioned place aversion to social interaction, whereas this was true for only 15% of the rats. In support of the lesser likelihood of mice to develop a preference for social interaction, the average amount of time spent in direct contact was 17% for mice vs 79% for rats. In animals that were concurrently conditioned for social interaction vs cocaine, the relative reward strength for cocaine was 300-fold higher in mice than in rats.Considering that human addicts regularly prefer drugs of abuse to drug-free social interaction, the present findings suggest that our experimental paradigm of concurrent CPP for cocaine vs social interaction is of even greater translational power if performed in C57BL/6 mice, the genetic background for most transgenic rodent models, than in rats. |
| first_indexed | 2024-04-13T00:17:23Z |
| format | Article |
| id | doaj.art-e3505ad7be164e8ca473610a00a5bfd2 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-04-13T00:17:23Z |
| publishDate | 2014-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-e3505ad7be164e8ca473610a00a5bfd22022-12-22T03:10:53ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532014-10-01810.3389/fnbeh.2014.00363112682Differences in social interaction- vs cocaine reward in rat vs mouseKai K Kummer0Lena eHofhansel1Constanze M Barwitz2Aurelia eSchardl3Janine Maria Prast4Ahmad eSalti5Rana eEl Rawas6Gerald eZernig7Gerald eZernig8Medical University of InnsbruckMedical University of InnsbruckMedical University of InnsbruckMedical University of InnsbruckMedical University of InnsbruckMedical University of InnsbruckMedical University of InnsbruckMedical University of InnsbruckUniversity of InnsbruckWe previously developed rat experimental models based on the conditioned place preference (CPP) paradigm in which only four 15-min episodes of dyadic social interaction with a sex- and weight-matched male Sprague Dawley rat (1) reversed CPP from cocaine to social interaction despite continuing cocaine training, and (2) prevented the reacquisition/re-expression of cocaine CPP. In a concurrent conditioning schedule, pairing one compartment with social interaction and the other compartment with 15 mg/kg cocaine injections, rats spent the same amount of time in both compartments and the most rewarding sensory component of the composite stimulus social interaction was touch (taction). In the present study, we validated our experimental paradigm in C57BL/6 mice to investigate if our experimental paradigm may be useful for the considerable number of genetically modified mouse models. Only 71% of the tested mice developed place preference for social interaction, whereas 85% of the rats did. Accordingly, 29% of the mice developed conditioned place aversion to social interaction, whereas this was true for only 15% of the rats. In support of the lesser likelihood of mice to develop a preference for social interaction, the average amount of time spent in direct contact was 17% for mice vs 79% for rats. In animals that were concurrently conditioned for social interaction vs cocaine, the relative reward strength for cocaine was 300-fold higher in mice than in rats.Considering that human addicts regularly prefer drugs of abuse to drug-free social interaction, the present findings suggest that our experimental paradigm of concurrent CPP for cocaine vs social interaction is of even greater translational power if performed in C57BL/6 mice, the genetic background for most transgenic rodent models, than in rats.http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00363/fullCocaineAddictionsubstance use disordersSprague Dawley ratC57BL/6 mouseconditioned place preference/aversion (CPP/CPA) |
| spellingShingle | Kai K Kummer Lena eHofhansel Constanze M Barwitz Aurelia eSchardl Janine Maria Prast Ahmad eSalti Rana eEl Rawas Gerald eZernig Gerald eZernig Differences in social interaction- vs cocaine reward in rat vs mouse Frontiers in Behavioral Neuroscience Cocaine Addiction substance use disorders Sprague Dawley rat C57BL/6 mouse conditioned place preference/aversion (CPP/CPA) |
| title | Differences in social interaction- vs cocaine reward in rat vs mouse |
| title_full | Differences in social interaction- vs cocaine reward in rat vs mouse |
| title_fullStr | Differences in social interaction- vs cocaine reward in rat vs mouse |
| title_full_unstemmed | Differences in social interaction- vs cocaine reward in rat vs mouse |
| title_short | Differences in social interaction- vs cocaine reward in rat vs mouse |
| title_sort | differences in social interaction vs cocaine reward in rat vs mouse |
| topic | Cocaine Addiction substance use disorders Sprague Dawley rat C57BL/6 mouse conditioned place preference/aversion (CPP/CPA) |
| url | http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00363/full |
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