Comparative genomic analysis of Brucella melitensis vaccine strain M5 provides insights into virulence attenuation.

The Brucella melitensis vaccine strain M5 is widely used to prevent and control brucellosis in animals. In this study, we determined the whole-genome sequence of M5, and conducted a comprehensive comparative analysis against the whole-genome sequence of the virulent strain 16 M and other reference s...

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Bibliographic Details
Main Authors: Hai Jiang, Pengcheng Du, Wen Zhang, Heng Wang, Hongyan Zhao, Dongri Piao, Guozhong Tian, Chen Chen, Buyun Cui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3743847?pdf=render