Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus
<i>Background and objectives:</i> Diabetes mellitus represents a metabolic disorder the incidence of which has been on the increase in recent years. The well-known long-term complications of this disease encompass a wide spectrum of renal, neurological and cardiovascular conditions. The...
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MDPI AG
2019-09-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/55/9/596 |
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| author | Malgorzata Dec-Gilowska Marcin Trojnar Boguslaw Makaruk Marcin Czop Sylwia Przybylska-Kuc Barbara Mosiewicz-Madejska Grzegorz Dzida Jerzy Mosiewicz |
| author_facet | Malgorzata Dec-Gilowska Marcin Trojnar Boguslaw Makaruk Marcin Czop Sylwia Przybylska-Kuc Barbara Mosiewicz-Madejska Grzegorz Dzida Jerzy Mosiewicz |
| author_sort | Malgorzata Dec-Gilowska |
| collection | DOAJ |
| description | <i>Background and objectives:</i> Diabetes mellitus represents a metabolic disorder the incidence of which has been on the increase in recent years. The well-known long-term complications of this disease encompass a wide spectrum of renal, neurological and cardiovascular conditions. The aim of the study was to investigate the serum concentration of endothelial microparticles (EMPs) as well as selected noninvasive parameters of the ascending aorta stiffness calculated with echocardiography. <i>Materials and Methods:</i> 58 patients were enrolled in this study—38 subjects diagnosed with type 2 diabetes mellitus (T2DM) and 20 healthy controls. The analyzed populations did not differ significantly with respect to age, renal function, systolic and diastolic blood pressure. <i>Results:</i> The patients with T2DM and concomitant hypertension presented higher levels of EMPs in comparison with diabetic normotensive subjects. Among patients with T2DM and hypertension, aortic stiffness assessed with the elasticity index (Ep) was higher and the aortic compliance index (D) lower than in the diabetic normotensive group. No correlation between the amount of EMPs and lipid profile, C-reactive protein (CRP) level and glycemia, was observed in the studied group. There was, however, a statistically significant positive correlation between the creatinine level and amount of EMPs, while the negative relationship was documented for EMPs level and the estimated glomerular filtration rate (eGFR). <i>Conclusions:</i> Considering the elevated number of EMPs in diabetic patients with hypertension as well as the positive correlation between EMPs and serum creatinine level, EMPs assessment could be useful in identifying patients who are at high risk of organ damage due to diabetes mellitus. |
| first_indexed | 2024-03-12T05:51:58Z |
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| institution | Directory Open Access Journal |
| issn | 1010-660X |
| language | English |
| last_indexed | 2024-03-12T05:51:58Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-e353fae09dd54edcb31e39a963e965d52023-09-03T05:03:32ZengMDPI AGMedicina1010-660X2019-09-0155959610.3390/medicina55090596medicina55090596Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes MellitusMalgorzata Dec-Gilowska0Marcin Trojnar1Boguslaw Makaruk2Marcin Czop3Sylwia Przybylska-Kuc4Barbara Mosiewicz-Madejska5Grzegorz Dzida6Jerzy Mosiewicz7Chair and Department of Internal Diseases, Medical University of Lublin, 20-059 Lublin, PolandChair and Department of Internal Diseases, Medical University of Lublin, 20-059 Lublin, PolandChair and Department of Internal Diseases, Medical University of Lublin, 20-059 Lublin, PolandDepartment of Clinical Genetics, Medical University of Lublin, 20-059 Lublin, PolandChair and Department of Internal Diseases, Medical University of Lublin, 20-059 Lublin, PolandChair and Department of Internal Diseases, Medical University of Lublin, Students Medical Association, 20-059 Lublin, PolandChair and Department of Internal Diseases, Medical University of Lublin, 20-059 Lublin, PolandChair and Department of Internal Diseases, Medical University of Lublin, 20-059 Lublin, Poland<i>Background and objectives:</i> Diabetes mellitus represents a metabolic disorder the incidence of which has been on the increase in recent years. The well-known long-term complications of this disease encompass a wide spectrum of renal, neurological and cardiovascular conditions. The aim of the study was to investigate the serum concentration of endothelial microparticles (EMPs) as well as selected noninvasive parameters of the ascending aorta stiffness calculated with echocardiography. <i>Materials and Methods:</i> 58 patients were enrolled in this study—38 subjects diagnosed with type 2 diabetes mellitus (T2DM) and 20 healthy controls. The analyzed populations did not differ significantly with respect to age, renal function, systolic and diastolic blood pressure. <i>Results:</i> The patients with T2DM and concomitant hypertension presented higher levels of EMPs in comparison with diabetic normotensive subjects. Among patients with T2DM and hypertension, aortic stiffness assessed with the elasticity index (Ep) was higher and the aortic compliance index (D) lower than in the diabetic normotensive group. No correlation between the amount of EMPs and lipid profile, C-reactive protein (CRP) level and glycemia, was observed in the studied group. There was, however, a statistically significant positive correlation between the creatinine level and amount of EMPs, while the negative relationship was documented for EMPs level and the estimated glomerular filtration rate (eGFR). <i>Conclusions:</i> Considering the elevated number of EMPs in diabetic patients with hypertension as well as the positive correlation between EMPs and serum creatinine level, EMPs assessment could be useful in identifying patients who are at high risk of organ damage due to diabetes mellitus.https://www.mdpi.com/1010-660X/55/9/596aortic stiffnesstype 2 diabetes mellituselasticity indexcompliance index |
| spellingShingle | Malgorzata Dec-Gilowska Marcin Trojnar Boguslaw Makaruk Marcin Czop Sylwia Przybylska-Kuc Barbara Mosiewicz-Madejska Grzegorz Dzida Jerzy Mosiewicz Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus Medicina aortic stiffness type 2 diabetes mellitus elasticity index compliance index |
| title | Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus |
| title_full | Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus |
| title_fullStr | Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus |
| title_full_unstemmed | Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus |
| title_short | Circulating Endothelial Microparticles and Aortic Stiffness in Patients with Type 2 Diabetes Mellitus |
| title_sort | circulating endothelial microparticles and aortic stiffness in patients with type 2 diabetes mellitus |
| topic | aortic stiffness type 2 diabetes mellitus elasticity index compliance index |
| url | https://www.mdpi.com/1010-660X/55/9/596 |
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