Association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertension
Objective To explore the association of renal surface nodularity (RSN) with the increased adverse vascular event (AVE) risk in patients with arterial hypertension. Methods This cross-sectional study included patients with arterial hypertension aged 18–60 years who underwent contrasted computed tomog...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Clinical and Experimental Hypertension |
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| Online Access: | http://dx.doi.org/10.1080/10641963.2023.2228518 |
| _version_ | 1827813985373650944 |
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| author | Jiule Ding Jie Chen Jun Zhou Zhenxing Jiang Dehui Xiang Wei Xing |
| author_facet | Jiule Ding Jie Chen Jun Zhou Zhenxing Jiang Dehui Xiang Wei Xing |
| author_sort | Jiule Ding |
| collection | DOAJ |
| description | Objective To explore the association of renal surface nodularity (RSN) with the increased adverse vascular event (AVE) risk in patients with arterial hypertension. Methods This cross-sectional study included patients with arterial hypertension aged 18–60 years who underwent contrasted computed tomography (CT) of kidney from January 2012 to December 2020. The subjects were classified into AVE or not (non-AVE) matched with age (≤5 years) and sex. Their CT images were analyzed using both qualitative (semiRSN) and quantitative RSN (qRSN) methods, respectively. Their clinical characteristics included age, sex, systolic blood pressure (SBP), diastolic blood pressure, hypertension course, diabetes history, hyperlipidemia, and estimated glomerular filtration rate (eGFR). Results Compared with non-AVE group (n = 91), AVE (n = 91) was at lower age, higher SBP, and fewer rate of diabetes and hyperlipidemia history (all P < .01). Rate of positive semiRSN was higher in AVE than non-AVE (49.45% vs 14.29%, P < .001). qRSN was larger in AVE than non-AVE [1.03 (0.85, 1.33) vs 0.86 (0.75,1.03), P < .001]. The increased AVE was associated with semiRSN (odds ratio = 7.04, P < .001) and qRSN (odds ratio = 5.09, P = .003), respectively. For distinguishing AVE from non-AVE, the area under receiver operating characteristic was bigger in the models combining the clinical characteristics with either semiRSN or qRSN than that of semiRSN or qRSN alone (P ≤.01). Conclusion Among the patients with arterial hypertension aged 18–60 years, CT imaging-based RSN was associated with increased AVE risk. |
| first_indexed | 2024-03-11T23:39:23Z |
| format | Article |
| id | doaj.art-e356c91c14a64d21a0437902da7017cf |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:39:23Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-e356c91c14a64d21a0437902da7017cf2023-09-19T16:04:09ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062023-12-0145110.1080/10641963.2023.22285182228518Association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertensionJiule Ding0Jie Chen1Jun Zhou2Zhenxing Jiang3Dehui Xiang4Wei Xing5The Third Affiliated Hospital of Soochow Univesity, ChangzhouThe Third Affiliated Hospital of Soochow Univesity, ChangzhouThe Third Affiliated Hospital of Soochow Univesity, ChangzhouThe Third Affiliated Hospital of Soochow Univesity, ChangzhouSoochow University, SuzhouThe Third Affiliated Hospital of Soochow Univesity, ChangzhouObjective To explore the association of renal surface nodularity (RSN) with the increased adverse vascular event (AVE) risk in patients with arterial hypertension. Methods This cross-sectional study included patients with arterial hypertension aged 18–60 years who underwent contrasted computed tomography (CT) of kidney from January 2012 to December 2020. The subjects were classified into AVE or not (non-AVE) matched with age (≤5 years) and sex. Their CT images were analyzed using both qualitative (semiRSN) and quantitative RSN (qRSN) methods, respectively. Their clinical characteristics included age, sex, systolic blood pressure (SBP), diastolic blood pressure, hypertension course, diabetes history, hyperlipidemia, and estimated glomerular filtration rate (eGFR). Results Compared with non-AVE group (n = 91), AVE (n = 91) was at lower age, higher SBP, and fewer rate of diabetes and hyperlipidemia history (all P < .01). Rate of positive semiRSN was higher in AVE than non-AVE (49.45% vs 14.29%, P < .001). qRSN was larger in AVE than non-AVE [1.03 (0.85, 1.33) vs 0.86 (0.75,1.03), P < .001]. The increased AVE was associated with semiRSN (odds ratio = 7.04, P < .001) and qRSN (odds ratio = 5.09, P = .003), respectively. For distinguishing AVE from non-AVE, the area under receiver operating characteristic was bigger in the models combining the clinical characteristics with either semiRSN or qRSN than that of semiRSN or qRSN alone (P ≤.01). Conclusion Among the patients with arterial hypertension aged 18–60 years, CT imaging-based RSN was associated with increased AVE risk.http://dx.doi.org/10.1080/10641963.2023.2228518renal surface nodularityhypertensionsubclinical renal damageadverse vascular eventtomography |
| spellingShingle | Jiule Ding Jie Chen Jun Zhou Zhenxing Jiang Dehui Xiang Wei Xing Association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertension Clinical and Experimental Hypertension renal surface nodularity hypertension subclinical renal damage adverse vascular event tomography |
| title | Association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertension |
| title_full | Association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertension |
| title_fullStr | Association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertension |
| title_full_unstemmed | Association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertension |
| title_short | Association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertension |
| title_sort | association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertension |
| topic | renal surface nodularity hypertension subclinical renal damage adverse vascular event tomography |
| url | http://dx.doi.org/10.1080/10641963.2023.2228518 |
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