Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study
Veterinarians face the lack of a rapid, reliable, inexpensive, and treatment-sensitive metrological instrument reflecting feline osteoarthritis (OA) pain. The Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians (MI-CAT(V)) has been refined in 4 sub-sections, and we proposed its c...
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MDPI AG
2024-02-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/14/5/711 |
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| author | Aliénor Delsart Colombe Otis Vivian S. Y. Leung Émilie Labelle Maxim Moreau Marilyn Frezier Marlene Drag Johanne Martel-Pelletier Jean-Pierre Pelletier Eric Troncy |
| author_facet | Aliénor Delsart Colombe Otis Vivian S. Y. Leung Émilie Labelle Maxim Moreau Marilyn Frezier Marlene Drag Johanne Martel-Pelletier Jean-Pierre Pelletier Eric Troncy |
| author_sort | Aliénor Delsart |
| collection | DOAJ |
| description | Veterinarians face the lack of a rapid, reliable, inexpensive, and treatment-sensitive metrological instrument reflecting feline osteoarthritis (OA) pain. The Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians (MI-CAT(V)) has been refined in 4 sub-sections, and we proposed its concurrent validation. Cats naturally affected by OA (<i>n</i> = 32) were randomly distributed into 4 groups of firocoxib analgesic (Gr. A: 0.40; B: 0.25; C: 0.15, and P: 0.00 mg/kg bodyweight). They were assessed during Baseline, Treatment, and Recovery periods using MI-CAT(V) and objective outcomes (effort path, stairs assay compliance, and actimetry). The MI-CAT(V) total score correlated to the effort path and actimetry (Rho<sub>S</sub> = −0.501 to −0.453; <i>p</i> < 0.001), also being sensitive to treatment responsiveness. The pooled treatment group improved its total, gait, and body posture scores during Treatment compared to the Baseline, Recovery, and placebo group (<i>p</i> < 0.05). The MI-CAT(V) suggested a dose-(especially for Gr. B) and cluster-response. Cats in the moderate and severe MI-CAT(V) clusters responded to firocoxib with a remaining analgesic effect, while the mild cluster seemed less responsive and experienced a negative rebound effect. The MI-CAT(V) was validated for its OA pain severity discriminatory abilities and sensitivity to firocoxib treatment, providing a new perspective for individualized care. |
| first_indexed | 2024-04-25T00:37:01Z |
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| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-04-25T00:37:01Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Animals |
| spelling | doaj.art-e3599958e241467f88782507626b3ee52024-03-12T16:38:00ZengMDPI AGAnimals2076-26152024-02-0114571110.3390/ani14050711Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded StudyAliénor Delsart0Colombe Otis1Vivian S. Y. Leung2Émilie Labelle3Maxim Moreau4Marilyn Frezier5Marlene Drag6Johanne Martel-Pelletier7Jean-Pierre Pelletier8Eric Troncy9Groupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St-Hyacinthe, QC J2S 2M2, CanadaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St-Hyacinthe, QC J2S 2M2, CanadaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St-Hyacinthe, QC J2S 2M2, CanadaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St-Hyacinthe, QC J2S 2M2, CanadaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St-Hyacinthe, QC J2S 2M2, CanadaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St-Hyacinthe, QC J2S 2M2, CanadaBoehringer Ingelheim Animal Health, Fulton, MO 65251, USAOsteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), Montreal, QC H2X 0A9, CanadaOsteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), Montreal, QC H2X 0A9, CanadaGroupe de Recherche en Pharmacologie Animale du Québec (GREPAQ), Université de Montréal, St-Hyacinthe, QC J2S 2M2, CanadaVeterinarians face the lack of a rapid, reliable, inexpensive, and treatment-sensitive metrological instrument reflecting feline osteoarthritis (OA) pain. The Montreal Instrument for Cat Arthritis Testing, for Use by Veterinarians (MI-CAT(V)) has been refined in 4 sub-sections, and we proposed its concurrent validation. Cats naturally affected by OA (<i>n</i> = 32) were randomly distributed into 4 groups of firocoxib analgesic (Gr. A: 0.40; B: 0.25; C: 0.15, and P: 0.00 mg/kg bodyweight). They were assessed during Baseline, Treatment, and Recovery periods using MI-CAT(V) and objective outcomes (effort path, stairs assay compliance, and actimetry). The MI-CAT(V) total score correlated to the effort path and actimetry (Rho<sub>S</sub> = −0.501 to −0.453; <i>p</i> < 0.001), also being sensitive to treatment responsiveness. The pooled treatment group improved its total, gait, and body posture scores during Treatment compared to the Baseline, Recovery, and placebo group (<i>p</i> < 0.05). The MI-CAT(V) suggested a dose-(especially for Gr. B) and cluster-response. Cats in the moderate and severe MI-CAT(V) clusters responded to firocoxib with a remaining analgesic effect, while the mild cluster seemed less responsive and experienced a negative rebound effect. The MI-CAT(V) was validated for its OA pain severity discriminatory abilities and sensitivity to firocoxib treatment, providing a new perspective for individualized care.https://www.mdpi.com/2076-2615/14/5/711felineosteoarthritisfirocoxibpain scalemetrologyactimetry |
| spellingShingle | Aliénor Delsart Colombe Otis Vivian S. Y. Leung Émilie Labelle Maxim Moreau Marilyn Frezier Marlene Drag Johanne Martel-Pelletier Jean-Pierre Pelletier Eric Troncy Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study Animals feline osteoarthritis firocoxib pain scale metrology actimetry |
| title | Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study |
| title_full | Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study |
| title_fullStr | Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study |
| title_full_unstemmed | Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study |
| title_short | Concurrent Validation of MI-CAT(V), a Clinical Metrology Instrument for Veterinarians Assessing Osteoarthritis Pain in Cats, through Testing for Firocoxib Analgesic Efficacy in a Prospective, Randomized, Controlled, and Blinded Study |
| title_sort | concurrent validation of mi cat v a clinical metrology instrument for veterinarians assessing osteoarthritis pain in cats through testing for firocoxib analgesic efficacy in a prospective randomized controlled and blinded study |
| topic | feline osteoarthritis firocoxib pain scale metrology actimetry |
| url | https://www.mdpi.com/2076-2615/14/5/711 |
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