A novel collision tumour of myofibroblastoma and low-grade adenosquamous carcinoma in breast
Abstract Background Myofibroblastoma (MFB) and low-grade adenosquamous carcinoma (LGASC) are rare tumours in the breast, respectively. However, a collision tumour of the two types has never been reported. Case presentation A 42-year-old female presented with a palpable mass in diameter of about 2.5 ...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-06-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13000-020-00992-2 |
| _version_ | 1818509516850855936 |
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| author | Guang-Zhi Yang Shang-Hua Liang Xiao-Hong Shi |
| author_facet | Guang-Zhi Yang Shang-Hua Liang Xiao-Hong Shi |
| author_sort | Guang-Zhi Yang |
| collection | DOAJ |
| description | Abstract Background Myofibroblastoma (MFB) and low-grade adenosquamous carcinoma (LGASC) are rare tumours in the breast, respectively. However, a collision tumour of the two types has never been reported. Case presentation A 42-year-old female presented with a palpable mass in diameter of about 2.5 cm in the left breast. Morphologically, the lesion was predominately composed of bland spindle cells admixed with some islands of mature adipocytes and a few epithelial elements dispersing in infiltrating way which formed both tubule and solid structures. The mass showed low positive index of Ki-67. The spindle cells were strongly and diffusely positive for CD34, SMA, desmin, ER and PR. The epithelial elements were positive for CK and EMA, and negative for ER and PR completely. CK5/6 and P63 were positive in the outer-layer of the tubules and nearly all the cells of the solid nests. Conclusions A collision tumour of MFB and LGASC in breast is extremely rare and either component is supposed to be not overlooked. Excision and close follow-up are advised. |
| first_indexed | 2024-12-10T22:46:31Z |
| format | Article |
| id | doaj.art-e35a87166d674d31af44731da070926a |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-10T22:46:31Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-e35a87166d674d31af44731da070926a2022-12-22T01:30:34ZengBMCDiagnostic Pathology1746-15962020-06-011511610.1186/s13000-020-00992-2A novel collision tumour of myofibroblastoma and low-grade adenosquamous carcinoma in breastGuang-Zhi Yang0Shang-Hua Liang1Xiao-Hong Shi2Department of Pathology, Beijing Dian Medical Test Laboratory Co. LtdDepartment of Pathology, Beijing Dian Medical Test Laboratory Co. LtdDepartment of Pathology, Beijing Dian Medical Test Laboratory Co. LtdAbstract Background Myofibroblastoma (MFB) and low-grade adenosquamous carcinoma (LGASC) are rare tumours in the breast, respectively. However, a collision tumour of the two types has never been reported. Case presentation A 42-year-old female presented with a palpable mass in diameter of about 2.5 cm in the left breast. Morphologically, the lesion was predominately composed of bland spindle cells admixed with some islands of mature adipocytes and a few epithelial elements dispersing in infiltrating way which formed both tubule and solid structures. The mass showed low positive index of Ki-67. The spindle cells were strongly and diffusely positive for CD34, SMA, desmin, ER and PR. The epithelial elements were positive for CK and EMA, and negative for ER and PR completely. CK5/6 and P63 were positive in the outer-layer of the tubules and nearly all the cells of the solid nests. Conclusions A collision tumour of MFB and LGASC in breast is extremely rare and either component is supposed to be not overlooked. Excision and close follow-up are advised.http://link.springer.com/article/10.1186/s13000-020-00992-2Collision tumourMyofibroblastomaLow-grade adenosquamous carcinomaBreast |
| spellingShingle | Guang-Zhi Yang Shang-Hua Liang Xiao-Hong Shi A novel collision tumour of myofibroblastoma and low-grade adenosquamous carcinoma in breast Diagnostic Pathology Collision tumour Myofibroblastoma Low-grade adenosquamous carcinoma Breast |
| title | A novel collision tumour of myofibroblastoma and low-grade adenosquamous carcinoma in breast |
| title_full | A novel collision tumour of myofibroblastoma and low-grade adenosquamous carcinoma in breast |
| title_fullStr | A novel collision tumour of myofibroblastoma and low-grade adenosquamous carcinoma in breast |
| title_full_unstemmed | A novel collision tumour of myofibroblastoma and low-grade adenosquamous carcinoma in breast |
| title_short | A novel collision tumour of myofibroblastoma and low-grade adenosquamous carcinoma in breast |
| title_sort | novel collision tumour of myofibroblastoma and low grade adenosquamous carcinoma in breast |
| topic | Collision tumour Myofibroblastoma Low-grade adenosquamous carcinoma Breast |
| url | http://link.springer.com/article/10.1186/s13000-020-00992-2 |
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