Worsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong
Abstract Background While there are postulations that asthma is potentially associated with severe coronavirus disease 2019 (COVID-19), there has been conflicting results from studies on the impact mild-to-moderate COVID-19 on asthma control after recovery. Methods A case control study on the associ...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Respiratory Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12931-023-02363-z |
| _version_ | 1797863837068689408 |
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| author | Wang Chun Kwok Terence Chi Chun Tam David Chi Leung Lam Jackson Ka Chun Leung King Pui Florence Chan Shung Kay Samuel Chan Ka Yan Chiang Mary Sau Man Ip James Chung Man Ho |
| author_facet | Wang Chun Kwok Terence Chi Chun Tam David Chi Leung Lam Jackson Ka Chun Leung King Pui Florence Chan Shung Kay Samuel Chan Ka Yan Chiang Mary Sau Man Ip James Chung Man Ho |
| author_sort | Wang Chun Kwok |
| collection | DOAJ |
| description | Abstract Background While there are postulations that asthma is potentially associated with severe coronavirus disease 2019 (COVID-19), there has been conflicting results from studies on the impact mild-to-moderate COVID-19 on asthma control after recovery. Methods A case control study on the association between mild-to-moderate COVID-19 and asthma control post infection was conducted. The primary outcome was a reduction in Asthma Control Test (ACT) score by ≥ 3 points post-COVID infection. The secondary outcomes included the change in ACT score, the proportion of patient with ACT score who dropped to ≤ 15 on enrolment visit and the need for escalation of asthma maintenance therapy. Results Out of the total of 221 adult patients with asthma recruited, 111 had mild-to-moderate COVID-19 within 30 to 270 days prior to study enrolment. The adjusted odds ratio (aOR) for a reduction in ACT score by ≥ 3 points after COVID-19 was 3.105 (95% CI = 1.385–6.959, p = 0.006). The odds of escalation of asthma maintenance therapy by at least 1 Global Initiative for Asthma (GINA) step was 4.733 (95% CI = 1.151–19.467, p = 0.031) and asthma patient are more likely to become uncontrolled after COVID-19 [aOR = 5.509 (95% CI = 1.061–28.600, p = 0.042)]. Conclusion Mild-to-moderate COVID-19 among asthma patients, upon recovery, was associated with worsening of asthma symptom, lower ACT score, a higher need for escalation of asthma maintenance therapy and more uncontrolled asthma. |
| first_indexed | 2024-04-09T22:42:04Z |
| format | Article |
| id | doaj.art-e35ad755e8f3447e933e58d29672f9a4 |
| institution | Directory Open Access Journal |
| issn | 1465-993X |
| language | English |
| last_indexed | 2024-04-09T22:42:04Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-e35ad755e8f3447e933e58d29672f9a42023-03-22T12:08:10ZengBMCRespiratory Research1465-993X2023-02-012411810.1186/s12931-023-02363-zWorsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong KongWang Chun Kwok0Terence Chi Chun Tam1David Chi Leung Lam2Jackson Ka Chun Leung3King Pui Florence Chan4Shung Kay Samuel Chan5Ka Yan Chiang6Mary Sau Man Ip7James Chung Man Ho8Department of Medicine, The University of Hong Kong, Queen Mary HospitalDepartment of Medicine, The University of Hong Kong, Queen Mary HospitalDepartment of Medicine, The University of Hong Kong, Queen Mary HospitalDepartment of Medicine, The University of Hong Kong, Queen Mary HospitalDepartment of Medicine, The University of Hong Kong, Queen Mary HospitalDepartment of Medicine, The University of Hong Kong, Queen Mary HospitalDepartment of Medicine, The University of Hong Kong, Queen Mary HospitalDepartment of Medicine, The University of Hong Kong, Queen Mary HospitalDepartment of Medicine, The University of Hong Kong, Queen Mary HospitalAbstract Background While there are postulations that asthma is potentially associated with severe coronavirus disease 2019 (COVID-19), there has been conflicting results from studies on the impact mild-to-moderate COVID-19 on asthma control after recovery. Methods A case control study on the association between mild-to-moderate COVID-19 and asthma control post infection was conducted. The primary outcome was a reduction in Asthma Control Test (ACT) score by ≥ 3 points post-COVID infection. The secondary outcomes included the change in ACT score, the proportion of patient with ACT score who dropped to ≤ 15 on enrolment visit and the need for escalation of asthma maintenance therapy. Results Out of the total of 221 adult patients with asthma recruited, 111 had mild-to-moderate COVID-19 within 30 to 270 days prior to study enrolment. The adjusted odds ratio (aOR) for a reduction in ACT score by ≥ 3 points after COVID-19 was 3.105 (95% CI = 1.385–6.959, p = 0.006). The odds of escalation of asthma maintenance therapy by at least 1 Global Initiative for Asthma (GINA) step was 4.733 (95% CI = 1.151–19.467, p = 0.031) and asthma patient are more likely to become uncontrolled after COVID-19 [aOR = 5.509 (95% CI = 1.061–28.600, p = 0.042)]. Conclusion Mild-to-moderate COVID-19 among asthma patients, upon recovery, was associated with worsening of asthma symptom, lower ACT score, a higher need for escalation of asthma maintenance therapy and more uncontrolled asthma.https://doi.org/10.1186/s12931-023-02363-zCOVID-19AsthmaAsthma controlAsthma exacerbation |
| spellingShingle | Wang Chun Kwok Terence Chi Chun Tam David Chi Leung Lam Jackson Ka Chun Leung King Pui Florence Chan Shung Kay Samuel Chan Ka Yan Chiang Mary Sau Man Ip James Chung Man Ho Worsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong Respiratory Research COVID-19 Asthma Asthma control Asthma exacerbation |
| title | Worsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong |
| title_full | Worsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong |
| title_fullStr | Worsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong |
| title_full_unstemmed | Worsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong |
| title_short | Worsening of asthma control after recovery from mild to moderate COVID-19 in patients from Hong Kong |
| title_sort | worsening of asthma control after recovery from mild to moderate covid 19 in patients from hong kong |
| topic | COVID-19 Asthma Asthma control Asthma exacerbation |
| url | https://doi.org/10.1186/s12931-023-02363-z |
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