The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate
Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that si...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-05-01
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| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2021.1896349 |
| _version_ | 1797677113154732032 |
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| author | Poonam Kumari Shahriar Tarighi Thomas Braun Alessandro Ianni |
| author_facet | Poonam Kumari Shahriar Tarighi Thomas Braun Alessandro Ianni |
| author_sort | Poonam Kumari |
| collection | DOAJ |
| description | Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that sirtuin 7 (SIRT7) activates this pathway by directly deacetylating NPM following ultraviolet irradiation, indicating tumor-suppressive functions of SIRT7. |
| first_indexed | 2024-03-11T22:40:16Z |
| format | Article |
| id | doaj.art-e35b827f491d47b6ac3e08c13fe4bcf1 |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:40:16Z |
| publishDate | 2021-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-e35b827f491d47b6ac3e08c13fe4bcf12023-09-22T09:19:43ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562021-05-018310.1080/23723556.2021.18963491896349The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debatePoonam Kumari0Shahriar Tarighi1Thomas Braun2Alessandro Ianni3Max-Planck-Institute for Heart and Lung ResearchMax-Planck-Institute for Heart and Lung ResearchMax-Planck-Institute for Heart and Lung ResearchMax-Planck-Institute for Heart and Lung ResearchRelease of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that sirtuin 7 (SIRT7) activates this pathway by directly deacetylating NPM following ultraviolet irradiation, indicating tumor-suppressive functions of SIRT7.http://dx.doi.org/10.1080/23723556.2021.1896349sirt7nucleophosminp53nucleolusultraviolet irradiation |
| spellingShingle | Poonam Kumari Shahriar Tarighi Thomas Braun Alessandro Ianni The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate Molecular & Cellular Oncology sirt7 nucleophosmin p53 nucleolus ultraviolet irradiation |
| title | The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate |
| title_full | The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate |
| title_fullStr | The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate |
| title_full_unstemmed | The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate |
| title_short | The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate |
| title_sort | complex role of sirt7 in p53 stabilization nucleophosmin joins the debate |
| topic | sirt7 nucleophosmin p53 nucleolus ultraviolet irradiation |
| url | http://dx.doi.org/10.1080/23723556.2021.1896349 |
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