A Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, Suppresses the Growth of Anaplastic Meningiomas and Inhibits Immune Checkpoint Expression by Regulating STAT1

A Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, Suppresses the Growth of Anaplastic Meningiomas and Inhibits Immune Checkpoint Expression by Regulating STAT1

Anaplastic meningioma is classified as a World Health Organization (WHO) grade III tumor and shows a strong tendency to recur. Although the incidence of anaplastic meningioma is low, the high rate of recurrence and death still makes treatment a challenge. A proteomics analysis was performed to inves...

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Bibliographic Details
Main Authors: Yuxuan Deng, Boyi Hu, Yazhou Miao, Jing Wang, Shaodong Zhang, Hong Wan, Zhen Wu, Yifan Lv, Jie Feng, Nan Ji, Deric Park, Shuyu Hao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Oncology
Subjects:
anaplastic meningioma
NAMPT
NAMPT inhibitor
immune checkpoint
cell cycle
proteomics
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.836257/full

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