Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study
Abstract Background Although red blood cells (RBC) transfusion is known to be significantly associated with biochemical recurrence in patients undergoing open prostatectomy, its influence on biochemical recurrence after robot-assisted laparoscopic radical prostatectomy remains unclear. Therefore, th...
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| Format: | Article |
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BMC
2021-11-01
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| Series: | BMC Urology |
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| Online Access: | https://doi.org/10.1186/s12894-021-00926-0 |
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| author | Jiwon Han Young-Tae Jeon Jung-Hee Ryu Ah-Young Oh Hwanik Kim Yu Kyung Bae Chang-Hoon Koo |
| author_facet | Jiwon Han Young-Tae Jeon Jung-Hee Ryu Ah-Young Oh Hwanik Kim Yu Kyung Bae Chang-Hoon Koo |
| author_sort | Jiwon Han |
| collection | DOAJ |
| description | Abstract Background Although red blood cells (RBC) transfusion is known to be significantly associated with biochemical recurrence in patients undergoing open prostatectomy, its influence on biochemical recurrence after robot-assisted laparoscopic radical prostatectomy remains unclear. Therefore, this study aimed to validate the effect of RBC transfusion on the 5-year biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy. Methods This study retrospectively analyzed the medical records of patients who underwent robot-assisted laparoscopic radical prostatectomy at single tertiary academic hospital between October 2007 and December 2014. Univariate and multivariate Cox proportional hazard regression analysis was performed to identify any potential variables associated with 5-year biochemical recurrence. Results A total of 1311 patients were included in the final analysis. Of these, 30 patients (2.3%) were transfused with RBC either during robot-assisted laparoscopic radical prostatectomy or during their hospital stay, which corresponded to 5-year biochemical recurrence of 15.7%. Multivariate Cox proportional hazard regression analysis showed that RBC transfusion had no influence on the 5-year biochemical recurrence. Variables including pathologic T stage (Hazard ratio [HR] 3.5, 95% confidence interval [CI] 2.4–5.1 p < 0.001), N stage (HR 2.3, 95% CI 1.5–3.7, p < 0.001), Gleason score (HR 2.4, 95% CI 1.8–3.2, p < 0.001), and surgical margin (HR 2.0, 95% CI 1.5–2.8, p < 0.001) were independently associated with the 5-year biochemical recurrence. Conclusions RBC transfusion had no significant influence on the 5-year biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy. |
| first_indexed | 2024-12-19T03:23:23Z |
| format | Article |
| id | doaj.art-e361644c2a374831a482945a6f3d7449 |
| institution | Directory Open Access Journal |
| issn | 1471-2490 |
| language | English |
| last_indexed | 2024-12-19T03:23:23Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Urology |
| spelling | doaj.art-e361644c2a374831a482945a6f3d74492022-12-21T20:37:42ZengBMCBMC Urology1471-24902021-11-012111710.1186/s12894-021-00926-0Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective studyJiwon Han0Young-Tae Jeon1Jung-Hee Ryu2Ah-Young Oh3Hwanik Kim4Yu Kyung Bae5Chang-Hoon Koo6Department of Anesthesiology and Pain Medicine, Seoul National University Bundang HospitalDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang HospitalDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang HospitalDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang HospitalDepartment of Urology, Seoul National University Bundang HospitalDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang HospitalDepartment of Anesthesiology and Pain Medicine, Seoul National University Bundang HospitalAbstract Background Although red blood cells (RBC) transfusion is known to be significantly associated with biochemical recurrence in patients undergoing open prostatectomy, its influence on biochemical recurrence after robot-assisted laparoscopic radical prostatectomy remains unclear. Therefore, this study aimed to validate the effect of RBC transfusion on the 5-year biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy. Methods This study retrospectively analyzed the medical records of patients who underwent robot-assisted laparoscopic radical prostatectomy at single tertiary academic hospital between October 2007 and December 2014. Univariate and multivariate Cox proportional hazard regression analysis was performed to identify any potential variables associated with 5-year biochemical recurrence. Results A total of 1311 patients were included in the final analysis. Of these, 30 patients (2.3%) were transfused with RBC either during robot-assisted laparoscopic radical prostatectomy or during their hospital stay, which corresponded to 5-year biochemical recurrence of 15.7%. Multivariate Cox proportional hazard regression analysis showed that RBC transfusion had no influence on the 5-year biochemical recurrence. Variables including pathologic T stage (Hazard ratio [HR] 3.5, 95% confidence interval [CI] 2.4–5.1 p < 0.001), N stage (HR 2.3, 95% CI 1.5–3.7, p < 0.001), Gleason score (HR 2.4, 95% CI 1.8–3.2, p < 0.001), and surgical margin (HR 2.0, 95% CI 1.5–2.8, p < 0.001) were independently associated with the 5-year biochemical recurrence. Conclusions RBC transfusion had no significant influence on the 5-year biochemical recurrence in patients undergoing robot-assisted laparoscopic radical prostatectomy.https://doi.org/10.1186/s12894-021-00926-0Biochemical recurrenceRed blood cell transfusionRobot-assisted laparoscopic radical prostatectomyProstate cancer |
| spellingShingle | Jiwon Han Young-Tae Jeon Jung-Hee Ryu Ah-Young Oh Hwanik Kim Yu Kyung Bae Chang-Hoon Koo Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study BMC Urology Biochemical recurrence Red blood cell transfusion Robot-assisted laparoscopic radical prostatectomy Prostate cancer |
| title | Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study |
| title_full | Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study |
| title_fullStr | Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study |
| title_full_unstemmed | Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study |
| title_short | Blood transfusion had no influence on the 5-year biochemical recurrence after robot-assisted radical prostatectomy: a retrospective study |
| title_sort | blood transfusion had no influence on the 5 year biochemical recurrence after robot assisted radical prostatectomy a retrospective study |
| topic | Biochemical recurrence Red blood cell transfusion Robot-assisted laparoscopic radical prostatectomy Prostate cancer |
| url | https://doi.org/10.1186/s12894-021-00926-0 |
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