Modeling abnormal priming in Alzheimer's patients with a free association network.
Alzheimer's Disease irremediably alters the proficiency of word search and retrieval processes even at its early stages. Such disruption can sometimes be paradoxical in specific language tasks, for example semantic priming. Here we focus in the striking side-effect of hyperpriming in Alzheimer&...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3148236?pdf=render |
| _version_ | 1819014471224393728 |
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| author | Javier Borge-Holthoefer Yamir Moreno Alex Arenas |
| author_facet | Javier Borge-Holthoefer Yamir Moreno Alex Arenas |
| author_sort | Javier Borge-Holthoefer |
| collection | DOAJ |
| description | Alzheimer's Disease irremediably alters the proficiency of word search and retrieval processes even at its early stages. Such disruption can sometimes be paradoxical in specific language tasks, for example semantic priming. Here we focus in the striking side-effect of hyperpriming in Alzheimer's Disease patients, which has been well-established in the literature for a long time. Previous studies have evidenced that modern network theory can become a powerful complementary tool to gain insight in cognitive phenomena. Here, we first show that network modeling is an appropriate approach to account for semantic priming in normal subjects. Then we turn to priming in degraded cognition: hyperpriming can be readily understood in the scope of a progressive degradation of the semantic network structure. We compare our simulation results with previous empirical observations in diseased patients finding a qualitative agreement. The network approach presented here can be used to accommodate current theories about impaired cognition, and towards a better understanding of lexical organization in healthy and diseased patients. |
| first_indexed | 2024-12-21T02:16:22Z |
| format | Article |
| id | doaj.art-e3634214536d4bd2ada6ea04fe7dbcfd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T02:16:22Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e3634214536d4bd2ada6ea04fe7dbcfd2022-12-21T19:19:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0168e2265110.1371/journal.pone.0022651Modeling abnormal priming in Alzheimer's patients with a free association network.Javier Borge-HolthoeferYamir MorenoAlex ArenasAlzheimer's Disease irremediably alters the proficiency of word search and retrieval processes even at its early stages. Such disruption can sometimes be paradoxical in specific language tasks, for example semantic priming. Here we focus in the striking side-effect of hyperpriming in Alzheimer's Disease patients, which has been well-established in the literature for a long time. Previous studies have evidenced that modern network theory can become a powerful complementary tool to gain insight in cognitive phenomena. Here, we first show that network modeling is an appropriate approach to account for semantic priming in normal subjects. Then we turn to priming in degraded cognition: hyperpriming can be readily understood in the scope of a progressive degradation of the semantic network structure. We compare our simulation results with previous empirical observations in diseased patients finding a qualitative agreement. The network approach presented here can be used to accommodate current theories about impaired cognition, and towards a better understanding of lexical organization in healthy and diseased patients.http://europepmc.org/articles/PMC3148236?pdf=render |
| spellingShingle | Javier Borge-Holthoefer Yamir Moreno Alex Arenas Modeling abnormal priming in Alzheimer's patients with a free association network. PLoS ONE |
| title | Modeling abnormal priming in Alzheimer's patients with a free association network. |
| title_full | Modeling abnormal priming in Alzheimer's patients with a free association network. |
| title_fullStr | Modeling abnormal priming in Alzheimer's patients with a free association network. |
| title_full_unstemmed | Modeling abnormal priming in Alzheimer's patients with a free association network. |
| title_short | Modeling abnormal priming in Alzheimer's patients with a free association network. |
| title_sort | modeling abnormal priming in alzheimer s patients with a free association network |
| url | http://europepmc.org/articles/PMC3148236?pdf=render |
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