Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent

Hydroxysteroid sulfotransferase 2B1 affects gastric epithelial function and carcinogenesis induced by a carcinogenic agent

Abstract Background A healthy gastric mucosal epithelium exhibits tumor-suppressive properties. Gastric epithelial cell dysfunction contributes to gastric cancer development. Oxysterols provided from food or cholesterol oxidation in the gastric epithelium may be further sulfated by hydroxysteroid su...

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Bibliographic Details
Main Authors: Wenting Hong, Fenghua Guo, Mingjie Yang, Dongke Xu, Ziyan Zhuang, Baolin Niu, Qianming Bai, Xiaobo Li
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Lipids in Health and Disease
Subjects:
Gastric epithelial cell
Hydroxysteroid Sulfotransferase 2B1 (SULT2B1)
Gastric carcinogenesis
Oxysterol
PI3K/AKT signaling
Online Access:http://link.springer.com/article/10.1186/s12944-019-1149-6

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