Signet-ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage: a case report and literature review
Abstract Background Primary duodenal cancer (PDC) is rare, especially signet-ring cell carcinoma (SRCC) of the duodenal bulb, and it is commonly misdiagnosed as an ulceration. Here, we report a rare case of SRCC of the duodenal bulb presenting with gastrointestinal hemorrhage in an 82-year-old man....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-05-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12876-022-02267-0 |
| _version_ | 1828793610095558656 |
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| author | Nan Ye Xiaoxiao Bao Xiaokang Zhao Bin Wang |
| author_facet | Nan Ye Xiaoxiao Bao Xiaokang Zhao Bin Wang |
| author_sort | Nan Ye |
| collection | DOAJ |
| description | Abstract Background Primary duodenal cancer (PDC) is rare, especially signet-ring cell carcinoma (SRCC) of the duodenal bulb, and it is commonly misdiagnosed as an ulceration. Here, we report a rare case of SRCC of the duodenal bulb presenting with gastrointestinal hemorrhage in an 82-year-old man. Case presentation An 82-year-old man was admitted for gastrointestinal hemorrhage. Physical examination revealed upper abdominal tenderness and pale appearance, but was otherwise unrevealing. Laboratory workup was significant for anemia. Imaging showed no abnormalities. Two endoscopic evaluations along with interventional embolization were attempted and, unfortunately, adequate hemostasis was not achieved, resulting in distal subtotal gastrectomy, including the duodenal bulb. SRCC of the duodenal bulb was diagnosed based on pathology after surgery. Post-operatively, the patient experienced persistent gastrointestinal bleeding. Family declined further intervention and the patient eventually died one month post-resection. Conclusions SRCC in the duodenal bulb is difficult to diagnose. For those with high-risk factors, endoscopic examination and biopsy are recommended. For patients who can receive radical tumor resection, pancreaticoduodenectomy (PD) is considered a first-line option. Early diagnosis and resection have been shown to improve prognosis. |
| first_indexed | 2024-12-12T03:30:31Z |
| format | Article |
| id | doaj.art-e364b7a8934547f495d265594a6e490a |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-12T03:30:31Z |
| publishDate | 2022-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-e364b7a8934547f495d265594a6e490a2022-12-22T00:39:56ZengBMCBMC Gastroenterology1471-230X2022-05-012211610.1186/s12876-022-02267-0Signet-ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage: a case report and literature reviewNan Ye0Xiaoxiao Bao1Xiaokang Zhao2Bin Wang3Department of Hepatobiliary Surgery, Dongyang People’s HospitalDepartment of Pathology, Dongyang People’s HospitalDepartment of Gastrointestinal Surgery, Dongyang People’s HospitalDepartment of Hepatobiliary Surgery, Dongyang People’s HospitalAbstract Background Primary duodenal cancer (PDC) is rare, especially signet-ring cell carcinoma (SRCC) of the duodenal bulb, and it is commonly misdiagnosed as an ulceration. Here, we report a rare case of SRCC of the duodenal bulb presenting with gastrointestinal hemorrhage in an 82-year-old man. Case presentation An 82-year-old man was admitted for gastrointestinal hemorrhage. Physical examination revealed upper abdominal tenderness and pale appearance, but was otherwise unrevealing. Laboratory workup was significant for anemia. Imaging showed no abnormalities. Two endoscopic evaluations along with interventional embolization were attempted and, unfortunately, adequate hemostasis was not achieved, resulting in distal subtotal gastrectomy, including the duodenal bulb. SRCC of the duodenal bulb was diagnosed based on pathology after surgery. Post-operatively, the patient experienced persistent gastrointestinal bleeding. Family declined further intervention and the patient eventually died one month post-resection. Conclusions SRCC in the duodenal bulb is difficult to diagnose. For those with high-risk factors, endoscopic examination and biopsy are recommended. For patients who can receive radical tumor resection, pancreaticoduodenectomy (PD) is considered a first-line option. Early diagnosis and resection have been shown to improve prognosis.https://doi.org/10.1186/s12876-022-02267-0DuodenalBulbSignet-ring cell carcinoma |
| spellingShingle | Nan Ye Xiaoxiao Bao Xiaokang Zhao Bin Wang Signet-ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage: a case report and literature review BMC Gastroenterology Duodenal Bulb Signet-ring cell carcinoma |
| title | Signet-ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage: a case report and literature review |
| title_full | Signet-ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage: a case report and literature review |
| title_fullStr | Signet-ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage: a case report and literature review |
| title_full_unstemmed | Signet-ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage: a case report and literature review |
| title_short | Signet-ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage: a case report and literature review |
| title_sort | signet ring cell carcinoma of the duodenal bulb presenting with gastrointestinal hemorrhage a case report and literature review |
| topic | Duodenal Bulb Signet-ring cell carcinoma |
| url | https://doi.org/10.1186/s12876-022-02267-0 |
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