Clinical significance of kidney immune complex deposition in children with acute interstitial nephritis disease
AbstractBackground Acute interstitial nephritis (AIN) is a relatively rare cause of acute kidney injury (AKI) in children. Immune complex (IC) deposition was rare in renal pathology of AIN.Methods Based on the status and position of IC deposition, a total of 78 children with AIN were divided into tw...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2023-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2236234 |
| _version_ | 1797211843441197056 |
|---|---|
| author | Pei Zhang Xiao Yang Xu He Chun-Lin Gao Zheng-Kun Xia |
| author_facet | Pei Zhang Xiao Yang Xu He Chun-Lin Gao Zheng-Kun Xia |
| author_sort | Pei Zhang |
| collection | DOAJ |
| description | AbstractBackground Acute interstitial nephritis (AIN) is a relatively rare cause of acute kidney injury (AKI) in children. Immune complex (IC) deposition was rare in renal pathology of AIN.Methods Based on the status and position of IC deposition, a total of 78 children with AIN were divided into two groups: the non-IC group and IC group. IC group was further divided into two subgroups: intraglomerular (IG)-IC group and extraglomerular (EG)-IC group. To compare the clinical and histological features, renal outcomes between groups.Results The IC deposition, IG-IC and EG-IC deposition were observed in 22 (28.21%), 12 (15.38%) and 10 (12.82%) children, respectively. The IC group demonstrated a higher frequency of AKI, higher level of Scr, urine N-acetyl-β-D-glucosidase (NAG) enzyme, retinol-binding protein (RBP), neutrophil gelatinase-associated lipocalin (NGAL), higher frequency of neutrophils, plasma cells and eosinophils infiltrate, higher scores of interstitial inflammation (i), total inflammation (ti) and interstitial edema, lower level of estimated glomerular filtration rate (eGFR) as compared to non-IC group (p < 0.05, p < 0.01). EG-IC deposition positively moderate correlated with levels of RBP, IG-IC deposition positively moderate correlated with plasma cell infiltrate, interstitial inflammation (i), total inflammation (ti) and interstitial edema. Interstitial inflammation, EG-IC deposition and interstitial edema were risk factors for AKD in AIN, and interstitial fibrosis/tubular atrophy (IF/TA) was a risk factor for CKD in children with AIN.Conclusion IG-IC and EG-IC deposition positively correlated with severe clinical manifestations, glomerular and tubular injuries, and EG-IC deposition was risk factor for the progression of AIN in children. |
| first_indexed | 2024-03-11T23:45:31Z |
| format | Article |
| id | doaj.art-e365a42553aa4d6792b1e9e9b56423f8 |
| institution | Directory Open Access Journal |
| issn | 0886-022X 1525-6049 |
| language | English |
| last_indexed | 2024-04-24T10:32:56Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj.art-e365a42553aa4d6792b1e9e9b56423f82024-04-12T14:34:28ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145210.1080/0886022X.2023.2236234Clinical significance of kidney immune complex deposition in children with acute interstitial nephritis diseasePei Zhang0Xiao Yang1Xu He2Chun-Lin Gao3Zheng-Kun Xia4Department of Paediatrics, Jinling HospitalSchool of Medicine, Nanjing University, Nanjing, P.R. ChinaDepartment of Paediatrics, Jinling HospitalSchool of Medicine, Nanjing University, Nanjing, P.R. ChinaDepartment of Paediatrics, Jinling HospitalSchool of Medicine, Nanjing University, Nanjing, P.R. ChinaDepartment of Paediatrics, Jinling HospitalSchool of Medicine, Nanjing University, Nanjing, P.R. ChinaDepartment of Paediatrics, Jinling HospitalSchool of Medicine, Nanjing University, Nanjing, P.R. ChinaAbstractBackground Acute interstitial nephritis (AIN) is a relatively rare cause of acute kidney injury (AKI) in children. Immune complex (IC) deposition was rare in renal pathology of AIN.Methods Based on the status and position of IC deposition, a total of 78 children with AIN were divided into two groups: the non-IC group and IC group. IC group was further divided into two subgroups: intraglomerular (IG)-IC group and extraglomerular (EG)-IC group. To compare the clinical and histological features, renal outcomes between groups.Results The IC deposition, IG-IC and EG-IC deposition were observed in 22 (28.21%), 12 (15.38%) and 10 (12.82%) children, respectively. The IC group demonstrated a higher frequency of AKI, higher level of Scr, urine N-acetyl-β-D-glucosidase (NAG) enzyme, retinol-binding protein (RBP), neutrophil gelatinase-associated lipocalin (NGAL), higher frequency of neutrophils, plasma cells and eosinophils infiltrate, higher scores of interstitial inflammation (i), total inflammation (ti) and interstitial edema, lower level of estimated glomerular filtration rate (eGFR) as compared to non-IC group (p < 0.05, p < 0.01). EG-IC deposition positively moderate correlated with levels of RBP, IG-IC deposition positively moderate correlated with plasma cell infiltrate, interstitial inflammation (i), total inflammation (ti) and interstitial edema. Interstitial inflammation, EG-IC deposition and interstitial edema were risk factors for AKD in AIN, and interstitial fibrosis/tubular atrophy (IF/TA) was a risk factor for CKD in children with AIN.Conclusion IG-IC and EG-IC deposition positively correlated with severe clinical manifestations, glomerular and tubular injuries, and EG-IC deposition was risk factor for the progression of AIN in children.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2236234Acute interstitial nephritisimmune complex depositionrenal pathologyprognosis |
| spellingShingle | Pei Zhang Xiao Yang Xu He Chun-Lin Gao Zheng-Kun Xia Clinical significance of kidney immune complex deposition in children with acute interstitial nephritis disease Renal Failure Acute interstitial nephritis immune complex deposition renal pathology prognosis |
| title | Clinical significance of kidney immune complex deposition in children with acute interstitial nephritis disease |
| title_full | Clinical significance of kidney immune complex deposition in children with acute interstitial nephritis disease |
| title_fullStr | Clinical significance of kidney immune complex deposition in children with acute interstitial nephritis disease |
| title_full_unstemmed | Clinical significance of kidney immune complex deposition in children with acute interstitial nephritis disease |
| title_short | Clinical significance of kidney immune complex deposition in children with acute interstitial nephritis disease |
| title_sort | clinical significance of kidney immune complex deposition in children with acute interstitial nephritis disease |
| topic | Acute interstitial nephritis immune complex deposition renal pathology prognosis |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2236234 |
| work_keys_str_mv | AT peizhang clinicalsignificanceofkidneyimmunecomplexdepositioninchildrenwithacuteinterstitialnephritisdisease AT xiaoyang clinicalsignificanceofkidneyimmunecomplexdepositioninchildrenwithacuteinterstitialnephritisdisease AT xuhe clinicalsignificanceofkidneyimmunecomplexdepositioninchildrenwithacuteinterstitialnephritisdisease AT chunlingao clinicalsignificanceofkidneyimmunecomplexdepositioninchildrenwithacuteinterstitialnephritisdisease AT zhengkunxia clinicalsignificanceofkidneyimmunecomplexdepositioninchildrenwithacuteinterstitialnephritisdisease |