Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

Dimethylfumarate inhibits microglial and astrocytic inflammation by suppressing the synthesis of nitric oxide, IL-1β, TNF-α and IL-6 in an in-vitro model of brain inflammation

<p>Abstract</p> <p>Background</p> <p>Brain inflammation plays a central role in multiple sclerosis (MS). Dimethylfumarate (DMF), the main ingredient of an oral formulation of fumaric acid esters with proven therapeutic efficacy in psoriasis, has recently been found to a...

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Bibliographic Details
Main Authors: Mrowietz Ulrich, Rickert Uta, Rostami-Yazdi Martin, Sievers Jobst, Wilms Henrik, Lucius Ralph
Format: Article
Language:English
Published: BMC 2010-05-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/7/1/30

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