Valproate induced hyperammonemic encephalopathy treated by haemodialysis
Valproate (VPA)-induced hyperammonemic encephalopathy is an unusual, but serious, adverse effect of divalproex sodium (DVPX) treatment and if untreated can lead to raised intracranial pressure, seizures, coma, and eventually death. It can, however, be reversed if an early diagnosis is made. It is th...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Industrial Psychiatry Journal |
| Subjects: | |
| Online Access: | http://www.industrialpsychiatry.org/article.asp?issn=0972-6748;year=2017;volume=26;issue=1;spage=99;epage=102;aulast=Chauhan |
| _version_ | 1818320661956788224 |
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| author | Vinay Singh Chauhan Siddarth Dixit Sunil Goyal Sudip Azad |
| author_facet | Vinay Singh Chauhan Siddarth Dixit Sunil Goyal Sudip Azad |
| author_sort | Vinay Singh Chauhan |
| collection | DOAJ |
| description | Valproate (VPA)-induced hyperammonemic encephalopathy is an unusual, but serious, adverse effect of divalproex sodium (DVPX) treatment and if untreated can lead to raised intracranial pressure, seizures, coma, and eventually death. It can, however, be reversed if an early diagnosis is made. It is therefore extremely important to recognize it and discontinue DVPX treatment. Our patient developed sudden deterioration of sensorium, drowsiness, lethargy, and later severe comatose state after few days of starting DVPX with high levels of serum ammonia despite therapeutic levels of VPA and normal liver function test. He responded to hemodialysis, cerebral decongestants, and other intensive supportive measures. |
| first_indexed | 2024-12-13T10:28:34Z |
| format | Article |
| id | doaj.art-e36665dea1f94f94aaa8e53b1a8a8d18 |
| institution | Directory Open Access Journal |
| issn | 0972-6748 0976-2795 |
| language | English |
| last_indexed | 2024-12-13T10:28:34Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Industrial Psychiatry Journal |
| spelling | doaj.art-e36665dea1f94f94aaa8e53b1a8a8d182022-12-21T23:50:56ZengWolters Kluwer Medknow PublicationsIndustrial Psychiatry Journal0972-67480976-27952017-01-012619910210.4103/ipj.ipj_37_16Valproate induced hyperammonemic encephalopathy treated by haemodialysisVinay Singh ChauhanSiddarth DixitSunil GoyalSudip AzadValproate (VPA)-induced hyperammonemic encephalopathy is an unusual, but serious, adverse effect of divalproex sodium (DVPX) treatment and if untreated can lead to raised intracranial pressure, seizures, coma, and eventually death. It can, however, be reversed if an early diagnosis is made. It is therefore extremely important to recognize it and discontinue DVPX treatment. Our patient developed sudden deterioration of sensorium, drowsiness, lethargy, and later severe comatose state after few days of starting DVPX with high levels of serum ammonia despite therapeutic levels of VPA and normal liver function test. He responded to hemodialysis, cerebral decongestants, and other intensive supportive measures.http://www.industrialpsychiatry.org/article.asp?issn=0972-6748;year=2017;volume=26;issue=1;spage=99;epage=102;aulast=ChauhanDivalproex sodiumencephalopathyhyperammonemia |
| spellingShingle | Vinay Singh Chauhan Siddarth Dixit Sunil Goyal Sudip Azad Valproate induced hyperammonemic encephalopathy treated by haemodialysis Industrial Psychiatry Journal Divalproex sodium encephalopathy hyperammonemia |
| title | Valproate induced hyperammonemic encephalopathy treated by haemodialysis |
| title_full | Valproate induced hyperammonemic encephalopathy treated by haemodialysis |
| title_fullStr | Valproate induced hyperammonemic encephalopathy treated by haemodialysis |
| title_full_unstemmed | Valproate induced hyperammonemic encephalopathy treated by haemodialysis |
| title_short | Valproate induced hyperammonemic encephalopathy treated by haemodialysis |
| title_sort | valproate induced hyperammonemic encephalopathy treated by haemodialysis |
| topic | Divalproex sodium encephalopathy hyperammonemia |
| url | http://www.industrialpsychiatry.org/article.asp?issn=0972-6748;year=2017;volume=26;issue=1;spage=99;epage=102;aulast=Chauhan |
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