Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness
Androgenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment’s effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I–IV by the Norwood–Hamilton scale, were treated for 4 months with 5%...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/5/336 |
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| author | Irina N. Kondrakhina Dmitry A. Verbenko Alexander M. Zatevalov Eugenia R. Gatiatulina Alexandr A. Nikonorov Dmitrij G. Deryabin Alexey A. Kubanov |
| author_facet | Irina N. Kondrakhina Dmitry A. Verbenko Alexander M. Zatevalov Eugenia R. Gatiatulina Alexandr A. Nikonorov Dmitrij G. Deryabin Alexey A. Kubanov |
| author_sort | Irina N. Kondrakhina |
| collection | DOAJ |
| description | Androgenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment’s effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I–IV by the Norwood–Hamilton scale, were treated for 4 months with 5% topical minoxidil joints with corrections for trace element and vitamin imbalances. In most cases, the positive therapy’s effect was shown in the parietal but not in the occipital area, whereas that effect was observed in others. The attempts to associate the therapy’s effectiveness with initially defined genetic, hormonal, and metabolic parameters showed the absence of differences between groups with positive and negative outcomes. Among the studied nutrient parameters (Zn, Cu, Mg, Ca, Fe, and Se, as well as vitamins B12, E, D, and folic acid), differences between these groups was shown in zinc content only. The starting point from a zinc plasma level above 10 µmol/L likely provides the success of the subsequent conservative therapy and correlates with an increase in the hair density and diameter in the parietal area. The integral predictive value of the Zn plasma level was assessed as 72.3% (positive predictive value: −88%; and negative predictive value: −55%). |
| first_indexed | 2024-03-10T19:38:09Z |
| format | Article |
| id | doaj.art-e367741a9e0f437380bae1564d1013dd |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T19:38:09Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e367741a9e0f437380bae1564d1013dd2023-11-20T01:33:53ZengMDPI AGDiagnostics2075-44182020-05-0110533610.3390/diagnostics10050336Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s EffectivenessIrina N. Kondrakhina0Dmitry A. Verbenko1Alexander M. Zatevalov2Eugenia R. Gatiatulina3Alexandr A. Nikonorov4Dmitrij G. Deryabin5Alexey A. Kubanov6State Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, bldg 6, 107076 Moscow, RussiaState Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, bldg 6, 107076 Moscow, RussiaG.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, Admiral Makarov Sr., 10, 125212 Moscow, RussiaAll-Russian Research Institute of Medicinal and Aromatic Plants (VILAR), Grina St., 7, 117216 Moscow, RussiaState Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, bldg 6, 107076 Moscow, RussiaState Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, bldg 6, 107076 Moscow, RussiaState Research Center of Dermatovenereology and Cosmetology, Korolenko St., 3, bldg 6, 107076 Moscow, RussiaAndrogenic alopecia (AGA) is the most common type of progressive hair loss in man. The search for reliable predictors of the conservative treatment’s effectiveness is an urgent problem today. Forty-eight patients with AGA, stages I–IV by the Norwood–Hamilton scale, were treated for 4 months with 5% topical minoxidil joints with corrections for trace element and vitamin imbalances. In most cases, the positive therapy’s effect was shown in the parietal but not in the occipital area, whereas that effect was observed in others. The attempts to associate the therapy’s effectiveness with initially defined genetic, hormonal, and metabolic parameters showed the absence of differences between groups with positive and negative outcomes. Among the studied nutrient parameters (Zn, Cu, Mg, Ca, Fe, and Se, as well as vitamins B12, E, D, and folic acid), differences between these groups was shown in zinc content only. The starting point from a zinc plasma level above 10 µmol/L likely provides the success of the subsequent conservative therapy and correlates with an increase in the hair density and diameter in the parietal area. The integral predictive value of the Zn plasma level was assessed as 72.3% (positive predictive value: −88%; and negative predictive value: −55%).https://www.mdpi.com/2075-4418/10/5/336androgenic alopeciazincminoxidiltrace elementshormoneshair follicles |
| spellingShingle | Irina N. Kondrakhina Dmitry A. Verbenko Alexander M. Zatevalov Eugenia R. Gatiatulina Alexandr A. Nikonorov Dmitrij G. Deryabin Alexey A. Kubanov Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness Diagnostics androgenic alopecia zinc minoxidil trace elements hormones hair follicles |
| title | Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness |
| title_full | Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness |
| title_fullStr | Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness |
| title_full_unstemmed | Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness |
| title_short | Plasma Zinc Levels in Males with Androgenetic Alopecia as Possible Predictors of the Subsequent Conservative Therapy’s Effectiveness |
| title_sort | plasma zinc levels in males with androgenetic alopecia as possible predictors of the subsequent conservative therapy s effectiveness |
| topic | androgenic alopecia zinc minoxidil trace elements hormones hair follicles |
| url | https://www.mdpi.com/2075-4418/10/5/336 |
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