Dermatofibrosarcoma protuberans challenges: a case series and review of the literature
Abstract Background Dermatofibrosarcoma protuberans (DFSP) is a rare variant of skin sarcoma which is characterized by proliferation of spindle cells in a storiform pattern. Although it is mostly benign in its primary stages, it can cause a high burden of morbidity unless it is thoroughly excised. C...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Journal of Medical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13256-022-03728-6 |
| _version_ | 1797945912122671104 |
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| author | Somayeh Sheidaei Mahsa Salehi Fatemeh Abedian kenari Hamid Reza Jafari |
| author_facet | Somayeh Sheidaei Mahsa Salehi Fatemeh Abedian kenari Hamid Reza Jafari |
| author_sort | Somayeh Sheidaei |
| collection | DOAJ |
| description | Abstract Background Dermatofibrosarcoma protuberans (DFSP) is a rare variant of skin sarcoma which is characterized by proliferation of spindle cells in a storiform pattern. Although it is mostly benign in its primary stages, it can cause a high burden of morbidity unless it is thoroughly excised. Case presentation Here, we review six cases of DFSP which were characterized by skin lesions in various parts of the body. Patients were from 26 to 51 years old; four were Asian men and two were Asian women. Wide surgical excision was performed for all these patients and no extra treatment was considered. Samples were studied by hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) tests. Only one of our patients experienced recurrence after the initial surgery. Conclusion Determining the best surgical method is still a dilemma in the treatment of DFSP lesions. There are numerous studies to prove the efficacy of various surgical interventions. Although DFSP is not commonly known as a malignant skin lesion, delay in treatment will have a catastrophic impact on patients’ lives. Thus, applying an in-time surgical method (wide local excision in our cases) in treating DFSP is crucial in preventing recurrence as well as decreasing the morbidity burden of DFSP. |
| first_indexed | 2024-04-10T21:02:37Z |
| format | Article |
| id | doaj.art-e36abbabc1654245b129b82517f7183a |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-10T21:02:37Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-e36abbabc1654245b129b82517f7183a2023-01-22T12:14:51ZengBMCJournal of Medical Case Reports1752-19472023-01-011711810.1186/s13256-022-03728-6Dermatofibrosarcoma protuberans challenges: a case series and review of the literature Somayeh Sheidaei0Mahsa Salehi1Fatemeh Abedian kenari2Hamid Reza Jafari3Pathology, Mazandaran University of Medical SciencesPathology, Mazandaran University of Medical SciencesPathology, Mazandaran University of Medical SciencesGeneral surgery, Isfahan University of Medical SciencesAbstract Background Dermatofibrosarcoma protuberans (DFSP) is a rare variant of skin sarcoma which is characterized by proliferation of spindle cells in a storiform pattern. Although it is mostly benign in its primary stages, it can cause a high burden of morbidity unless it is thoroughly excised. Case presentation Here, we review six cases of DFSP which were characterized by skin lesions in various parts of the body. Patients were from 26 to 51 years old; four were Asian men and two were Asian women. Wide surgical excision was performed for all these patients and no extra treatment was considered. Samples were studied by hematoxylin and eosin (H&E) staining and immunohistochemical (IHC) tests. Only one of our patients experienced recurrence after the initial surgery. Conclusion Determining the best surgical method is still a dilemma in the treatment of DFSP lesions. There are numerous studies to prove the efficacy of various surgical interventions. Although DFSP is not commonly known as a malignant skin lesion, delay in treatment will have a catastrophic impact on patients’ lives. Thus, applying an in-time surgical method (wide local excision in our cases) in treating DFSP is crucial in preventing recurrence as well as decreasing the morbidity burden of DFSP.https://doi.org/10.1186/s13256-022-03728-6Dermatofibrosarcoma protuberans (DFSP)Wide local excision (WLE) |
| spellingShingle | Somayeh Sheidaei Mahsa Salehi Fatemeh Abedian kenari Hamid Reza Jafari Dermatofibrosarcoma protuberans challenges: a case series and review of the literature Journal of Medical Case Reports Dermatofibrosarcoma protuberans (DFSP) Wide local excision (WLE) |
| title | Dermatofibrosarcoma protuberans challenges: a case series and review of the literature |
| title_full | Dermatofibrosarcoma protuberans challenges: a case series and review of the literature |
| title_fullStr | Dermatofibrosarcoma protuberans challenges: a case series and review of the literature |
| title_full_unstemmed | Dermatofibrosarcoma protuberans challenges: a case series and review of the literature |
| title_short | Dermatofibrosarcoma protuberans challenges: a case series and review of the literature |
| title_sort | dermatofibrosarcoma protuberans challenges a case series and review of the literature |
| topic | Dermatofibrosarcoma protuberans (DFSP) Wide local excision (WLE) |
| url | https://doi.org/10.1186/s13256-022-03728-6 |
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