The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool?
Chronic inflammation and increased oxidative stress are contributing factors to many non-communicable diseases. A growing body of evidence indicates that dietary nutrients can activate the immune system and may lead to the overproduction of pro-inflammatory cytokines. Fatty acids as macronutrients a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/10/2/157 |
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| author | Pelagia Katsimbri Emmanouil Korakas Aikaterini Kountouri Ignatios Ikonomidis Elias Tsougos Dionysios Vlachos Evangelia Papadavid Athanasios Raptis Vaia Lambadiari |
| author_facet | Pelagia Katsimbri Emmanouil Korakas Aikaterini Kountouri Ignatios Ikonomidis Elias Tsougos Dionysios Vlachos Evangelia Papadavid Athanasios Raptis Vaia Lambadiari |
| author_sort | Pelagia Katsimbri |
| collection | DOAJ |
| description | Chronic inflammation and increased oxidative stress are contributing factors to many non-communicable diseases. A growing body of evidence indicates that dietary nutrients can activate the immune system and may lead to the overproduction of pro-inflammatory cytokines. Fatty acids as macronutrients are key players for immunomodulation, with n-3 polyunsaturated fatty acids having the most beneficial effect, while polyphenols and carotenoids seem to be the most promising antioxidants. Psoriasis is a chronic, immune-mediated inflammatory disease with multifactorial etiology. Obesity is a major risk factor for psoriasis, which leads to worse clinical outcomes. Weight loss interventions and, generally, dietary regimens such as gluten-free and Mediterranean diet or supplement use may potentially improve psoriasis’ natural course and response to therapy. However, data about more sophisticated nutritional patterns, such as ketogenic, very low-carb or specific macro- and micro-nutrient substitution, are scarce. This review aims to present the effect of strictly structured dietary nutrients, that are known to affect glucose/lipid metabolism and insulin responses, on chronic inflammation and immunity, and to discuss the utility of nutritional regimens as possible therapeutic tools for psoriasis and psoriatic arthritis. |
| first_indexed | 2024-03-09T03:59:56Z |
| format | Article |
| id | doaj.art-e36ccb55072c4598ae5ef12475cd640a |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T03:59:56Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-e36ccb55072c4598ae5ef12475cd640a2023-12-03T14:15:44ZengMDPI AGAntioxidants2076-39212021-01-0110215710.3390/antiox10020157The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool?Pelagia Katsimbri0Emmanouil Korakas1Aikaterini Kountouri2Ignatios Ikonomidis3Elias Tsougos4Dionysios Vlachos5Evangelia Papadavid6Athanasios Raptis7Vaia Lambadiari8Rheumatology and Clinical Immunology Unit, Fourth Department of Internal Medicine, Attikon Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Cardiology Department, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceDepartment of Cardiology, Heart Failure and Preventive Cardiology Section, Ygeia Hospital, 12462 Athens, GreeceIndependent Researcher, General Physician, 16451 Athens, GreeceSecond Department of Dermatology and Venereology, University of Athens Medical School, 12462 Athens, GreeceSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceSecond Department of Internal Medicine, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, 12462 Athens, GreeceChronic inflammation and increased oxidative stress are contributing factors to many non-communicable diseases. A growing body of evidence indicates that dietary nutrients can activate the immune system and may lead to the overproduction of pro-inflammatory cytokines. Fatty acids as macronutrients are key players for immunomodulation, with n-3 polyunsaturated fatty acids having the most beneficial effect, while polyphenols and carotenoids seem to be the most promising antioxidants. Psoriasis is a chronic, immune-mediated inflammatory disease with multifactorial etiology. Obesity is a major risk factor for psoriasis, which leads to worse clinical outcomes. Weight loss interventions and, generally, dietary regimens such as gluten-free and Mediterranean diet or supplement use may potentially improve psoriasis’ natural course and response to therapy. However, data about more sophisticated nutritional patterns, such as ketogenic, very low-carb or specific macro- and micro-nutrient substitution, are scarce. This review aims to present the effect of strictly structured dietary nutrients, that are known to affect glucose/lipid metabolism and insulin responses, on chronic inflammation and immunity, and to discuss the utility of nutritional regimens as possible therapeutic tools for psoriasis and psoriatic arthritis.https://www.mdpi.com/2076-3921/10/2/157inflammationimmunitynutrientsantioxidantsdietobesity |
| spellingShingle | Pelagia Katsimbri Emmanouil Korakas Aikaterini Kountouri Ignatios Ikonomidis Elias Tsougos Dionysios Vlachos Evangelia Papadavid Athanasios Raptis Vaia Lambadiari The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool? Antioxidants inflammation immunity nutrients antioxidants diet obesity |
| title | The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool? |
| title_full | The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool? |
| title_fullStr | The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool? |
| title_full_unstemmed | The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool? |
| title_short | The Effect of Antioxidant and Anti-Inflammatory Capacity of Diet on Psoriasis and Psoriatic Arthritis Phenotype: Nutrition as Therapeutic Tool? |
| title_sort | effect of antioxidant and anti inflammatory capacity of diet on psoriasis and psoriatic arthritis phenotype nutrition as therapeutic tool |
| topic | inflammation immunity nutrients antioxidants diet obesity |
| url | https://www.mdpi.com/2076-3921/10/2/157 |
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