Tamoxifen is effective in the treatment of Leishmania amazonensis infections in mice.

BACKGROUND: Chemotherapy is still a critical issue in the management of leishmaniasis. Until recently, pentavalent antimonials, amphotericin B or pentamidine compounded the classical arsenal of treatment. All these drugs are toxic and have to be administered by the parenteral route. Tamoxifen has be...

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Bibliographic Details
Main Authors: Danilo C Miguel, Jenicer K U Yokoyama-Yasunaka, Silvia R B Uliana
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:http://europepmc.org/articles/PMC2398787?pdf=render