Visceral fat and attribute-based medicine in chronic kidney disease
Visceral adipose tissue plays a central role in obesity and metabolic syndrome and is an independent risk factor for both cardiovascular and metabolic disorders. Increased visceral adipose tissue promotes adipokine dysregulation and insulin resistance, leading to several health issues, including sys...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-02-01
|
| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1097596/full |
| _version_ | 1811168435918340096 |
|---|---|
| author | Hiroshi Kataoka Kosaku Nitta Junichi Hoshino |
| author_facet | Hiroshi Kataoka Kosaku Nitta Junichi Hoshino |
| author_sort | Hiroshi Kataoka |
| collection | DOAJ |
| description | Visceral adipose tissue plays a central role in obesity and metabolic syndrome and is an independent risk factor for both cardiovascular and metabolic disorders. Increased visceral adipose tissue promotes adipokine dysregulation and insulin resistance, leading to several health issues, including systemic inflammation, oxidative stress, and activation of the renin-angiotensin-aldosterone system. Moreover, an increase in adipose tissue directly and indirectly affects the kidneys by increasing renal sodium reabsorption, causing glomerular hyperfiltration and hypertrophy, which leads to increased proteinuria and kidney fibrosis/dysfunction. Although the interest in the adverse effects of obesity on renal diseases has grown exponentially in recent years, the relationship between obesity and renal prognosis remains controversial. This may be attributed to the long clinical course of obesity, numerous obesity-related metabolic complications, and patients’ attributes. Multiple individual attributes influencing the pathophysiology of fat accumulation make it difficult to understand obesity. In such cases, it may be effective to elucidate the pathophysiology by conducting research tailored to individual attributes from the perspective of attribute-based medicine/personalized medicine. We consider the appropriate use of clinical indicators necessary, according to attributes such as chronic kidney disease stage, level of visceral adipose tissue accumulation, age, and sex. Selecting treatments and clinical indicators based on individual attributes will allow for advancements in the clinical management of patients with obesity and chronic kidney disease. In the clinical setting of obesity-related nephropathy, it is first necessary to accumulate attribute-based studies resulting from the accurate evaluation of visceral fat accumulation to establish evidence for promoting personalized medicine. |
| first_indexed | 2024-04-10T16:26:18Z |
| format | Article |
| id | doaj.art-e36d93976119461cb29ee20975bc9b1f |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-10T16:26:18Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-e36d93976119461cb29ee20975bc9b1f2023-02-09T05:57:44ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-02-011410.3389/fendo.2023.10975961097596Visceral fat and attribute-based medicine in chronic kidney diseaseHiroshi KataokaKosaku NittaJunichi HoshinoVisceral adipose tissue plays a central role in obesity and metabolic syndrome and is an independent risk factor for both cardiovascular and metabolic disorders. Increased visceral adipose tissue promotes adipokine dysregulation and insulin resistance, leading to several health issues, including systemic inflammation, oxidative stress, and activation of the renin-angiotensin-aldosterone system. Moreover, an increase in adipose tissue directly and indirectly affects the kidneys by increasing renal sodium reabsorption, causing glomerular hyperfiltration and hypertrophy, which leads to increased proteinuria and kidney fibrosis/dysfunction. Although the interest in the adverse effects of obesity on renal diseases has grown exponentially in recent years, the relationship between obesity and renal prognosis remains controversial. This may be attributed to the long clinical course of obesity, numerous obesity-related metabolic complications, and patients’ attributes. Multiple individual attributes influencing the pathophysiology of fat accumulation make it difficult to understand obesity. In such cases, it may be effective to elucidate the pathophysiology by conducting research tailored to individual attributes from the perspective of attribute-based medicine/personalized medicine. We consider the appropriate use of clinical indicators necessary, according to attributes such as chronic kidney disease stage, level of visceral adipose tissue accumulation, age, and sex. Selecting treatments and clinical indicators based on individual attributes will allow for advancements in the clinical management of patients with obesity and chronic kidney disease. In the clinical setting of obesity-related nephropathy, it is first necessary to accumulate attribute-based studies resulting from the accurate evaluation of visceral fat accumulation to establish evidence for promoting personalized medicine.https://www.frontiersin.org/articles/10.3389/fendo.2023.1097596/fullvisceral fatpatient-centered medicinesex differencepersonalized medicineobesityprecision medicine |
| spellingShingle | Hiroshi Kataoka Kosaku Nitta Junichi Hoshino Visceral fat and attribute-based medicine in chronic kidney disease Frontiers in Endocrinology visceral fat patient-centered medicine sex difference personalized medicine obesity precision medicine |
| title | Visceral fat and attribute-based medicine in chronic kidney disease |
| title_full | Visceral fat and attribute-based medicine in chronic kidney disease |
| title_fullStr | Visceral fat and attribute-based medicine in chronic kidney disease |
| title_full_unstemmed | Visceral fat and attribute-based medicine in chronic kidney disease |
| title_short | Visceral fat and attribute-based medicine in chronic kidney disease |
| title_sort | visceral fat and attribute based medicine in chronic kidney disease |
| topic | visceral fat patient-centered medicine sex difference personalized medicine obesity precision medicine |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1097596/full |
| work_keys_str_mv | AT hiroshikataoka visceralfatandattributebasedmedicineinchronickidneydisease AT kosakunitta visceralfatandattributebasedmedicineinchronickidneydisease AT junichihoshino visceralfatandattributebasedmedicineinchronickidneydisease |