Regulation of Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer
Rapidly evolving and ever-increasing knowledge of the molecular pathophysiology of pancreatic cancer has leveraged our understanding altogether to a next level. Compared to the exciting ground-breaking discoveries related to underlying mechanisms of pancreatic cancer onset and progression, however,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.657965/full |
| _version_ | 1818897951278235648 |
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| author | Ammad Ahmad Farooqi Sawera Nayyab Chiara Martinelli Rossana Berardi Hector Katifelis Maria Gazouli William C. Cho |
| author_facet | Ammad Ahmad Farooqi Sawera Nayyab Chiara Martinelli Rossana Berardi Hector Katifelis Maria Gazouli William C. Cho |
| author_sort | Ammad Ahmad Farooqi |
| collection | DOAJ |
| description | Rapidly evolving and ever-increasing knowledge of the molecular pathophysiology of pancreatic cancer has leveraged our understanding altogether to a next level. Compared to the exciting ground-breaking discoveries related to underlying mechanisms of pancreatic cancer onset and progression, however, there had been relatively few advances in the therapeutic options available for the treatment. Since the discovery of the DNA structure as a helix which replicates semi-conservatively to pass the genetic material to the progeny, there has been conceptual refinement and continuous addition of missing pieces to complete the landscape of central dogma. Starting from transcription to translation, modern era has witnessed non-coding RNA discovery and central role of these versatile regulators in onset and progression of pancreatic cancer. Long non-coding RNAs (lncRNAs) have been shown to act as competitive endogenous RNAs through sequestration and competitive binding to myriad of microRNAs in different cancers. In this article, we set spotlight on emerging evidence of regulation of different signaling pathways (Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT and NOTCH) by lncRNAs. Conceptual refinements have enabled us to understand how lncRNAs play central role in post-translational modifications of various proteins and how lncRNAs work with epigenetic-associated machinery to transcriptionally regulate gene network in pancreatic cancer. |
| first_indexed | 2024-12-19T19:24:20Z |
| format | Article |
| id | doaj.art-e36e256b30b348debf2fb9732530ccc6 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T19:24:20Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e36e256b30b348debf2fb9732530ccc62022-12-21T20:08:52ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-06-011110.3389/fonc.2021.657965657965Regulation of Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic CancerAmmad Ahmad Farooqi0Sawera Nayyab1Chiara Martinelli2Rossana Berardi3Hector Katifelis4Maria Gazouli5William C. Cho6Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, PakistanDepartment of Biotechnology, Faculty of Science, University of Sialkot, Sialkot, PakistanIndependent researcher, Como, ItalyUniversità Politecnica delle Marche-Ospedali Riuniti Ancona, Ancona, ItalyLaboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, GreeceLaboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, GreeceDepartment of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, ChinaRapidly evolving and ever-increasing knowledge of the molecular pathophysiology of pancreatic cancer has leveraged our understanding altogether to a next level. Compared to the exciting ground-breaking discoveries related to underlying mechanisms of pancreatic cancer onset and progression, however, there had been relatively few advances in the therapeutic options available for the treatment. Since the discovery of the DNA structure as a helix which replicates semi-conservatively to pass the genetic material to the progeny, there has been conceptual refinement and continuous addition of missing pieces to complete the landscape of central dogma. Starting from transcription to translation, modern era has witnessed non-coding RNA discovery and central role of these versatile regulators in onset and progression of pancreatic cancer. Long non-coding RNAs (lncRNAs) have been shown to act as competitive endogenous RNAs through sequestration and competitive binding to myriad of microRNAs in different cancers. In this article, we set spotlight on emerging evidence of regulation of different signaling pathways (Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT and NOTCH) by lncRNAs. Conceptual refinements have enabled us to understand how lncRNAs play central role in post-translational modifications of various proteins and how lncRNAs work with epigenetic-associated machinery to transcriptionally regulate gene network in pancreatic cancer.https://www.frontiersin.org/articles/10.3389/fonc.2021.657965/fulllncRNAapoptosissignaling pathwaysmicroRNApancreatic cancer |
| spellingShingle | Ammad Ahmad Farooqi Sawera Nayyab Chiara Martinelli Rossana Berardi Hector Katifelis Maria Gazouli William C. Cho Regulation of Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer Frontiers in Oncology lncRNA apoptosis signaling pathways microRNA pancreatic cancer |
| title | Regulation of Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer |
| title_full | Regulation of Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer |
| title_fullStr | Regulation of Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer |
| title_full_unstemmed | Regulation of Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer |
| title_short | Regulation of Hippo, TGFβ/SMAD, Wnt/β-Catenin, JAK/STAT, and NOTCH by Long Non-Coding RNAs in Pancreatic Cancer |
| title_sort | regulation of hippo tgfβ smad wnt β catenin jak stat and notch by long non coding rnas in pancreatic cancer |
| topic | lncRNA apoptosis signaling pathways microRNA pancreatic cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.657965/full |
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