Gastrointestinal pan-cancer landscape of tumor matrix heterogeneity identifies biologically distinct matrix stiffness subtypes predicting prognosis and chemotherapy efficacy

Gastrointestinal pan-cancer landscape of tumor matrix heterogeneity identifies biologically distinct matrix stiffness subtypes predicting prognosis and chemotherapy efficacy

Gastrointestinal (GI) cancers are a heterogeneous group of primary solid tumors, arising in GI tract from the esophagus to rectum. Matrix stiffness (MS) is a critical physical factor for cancer progression; however, its importance in tumor progression remains to be comprehensively recognized. Herein...

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Bibliographic Details
Main Authors: Yumei Ning, Kun Lin, Jun Fang, Yang Ding, Zhang Zhang, Xiaojia Chen, Qiu Zhao, Haizhou Wang, Fan Wang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Gastrointestinal cancer
Extracellular matrix
Matrix stiffness
Cancer subtype
Chemotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023001691

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