Comparison of intravitreal bevacizumab with macular photocoagulation for treatment of diabetic macular edema:a systemic review and Meta-analysis
<b>AIM:</b> To further evaluate the efficacy and safety of intravitreal bevacizumab (IVB) versus macular photocoagulation (MPC) in treatment of diabetic macular edema (DME) by Meta-analysis.<b>METHODS:</b> Pertinent publications were identified through systemic searches of Pu...
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2014-12-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270975/ |
| _version_ | 1819293906098978816 |
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| author | Xiang-Dong Liu Xiao-Dong Zhou Zhi Wang Hong-Jie Shen |
| author_facet | Xiang-Dong Liu Xiao-Dong Zhou Zhi Wang Hong-Jie Shen |
| author_sort | Xiang-Dong Liu |
| collection | DOAJ |
| description | <b>AIM:</b> To further evaluate the efficacy and safety of intravitreal bevacizumab (IVB) versus macular photocoagulation (MPC) in treatment of diabetic macular edema (DME) by Meta-analysis.<b>METHODS:</b> Pertinent publications were identified through systemic searches of PubMed, Medline, EMBASE, and the Cochrane Controlled Trials Register up to 30 November, 2013. Changes in central macular thickness (CMT) in μm and best-corrected visual acuity (BCVA) in logMAR equivalents were extracted at 1, 3, 6, 12 and 24mo after initial treatment, and a Meta-analysis was carried out to compare results between groups receiving IVB and MPC.<b>RESULTS:</b>Five randomized controlled trial (RCTs) and one high-quality comparative study were identified and included. Our Meta-analysis revealed that both IVB and MPC resulted in the improvements of CMT and BCVA in eyes with DME at 1mo after initial treatment, with IVB being significantly superior to MPC (<i>P</i>=0.01 and 0.02, respectively). The improvements of both measure outcomes at 3, 6, 12 and 24mo after treatment did not vary significantly between the IVB groups and MPC groups (CMT at 3mo, <i>P</i>=0.85; at 6mo, <i>P</i>=0.29; at 12mo, <i>P</i>=0.56; at 24mo, <i>P</i>=0.71; BCVA at 3mo, <i>P</i>=0.31; at 6mo, <i>P</i>= 0.30; at 12mo, <i>P</i>=0.23; at 24mo, <i>P</i>=0.52). However, the number of observed adverse events was low in all studies.<b>CONCLUSION:</b> Current evidence shows IVB treatment trends to be more effective in improvements of macular edema and vision in eyes with DME at an earlier follow up (1mo) compared with MPC. At other time, both interventions have comparable efficacy without statistical significances. |
| first_indexed | 2024-12-24T04:17:52Z |
| format | Article |
| id | doaj.art-e37012cbe9d9456497df672ecb6a44c0 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-24T04:17:52Z |
| publishDate | 2014-12-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-e37012cbe9d9456497df672ecb6a44c02022-12-21T17:15:54ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982014-12-01761048105510.3980/j.issn.2222-3959.2014.06.26Comparison of intravitreal bevacizumab with macular photocoagulation for treatment of diabetic macular edema:a systemic review and Meta-analysisXiang-Dong Liu0Xiao-Dong Zhou1Zhi Wang2Hong-Jie Shen3Department of Ophthalmology, Affiliated Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Ophthalmology, Affiliated Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Ophthalmology, Affiliated Jinshan Hospital, Fudan University, Shanghai 201508, ChinaDepartment of Ophthalmology, Affiliated Jinshan Hospital, Fudan University, Shanghai 201508, China<b>AIM:</b> To further evaluate the efficacy and safety of intravitreal bevacizumab (IVB) versus macular photocoagulation (MPC) in treatment of diabetic macular edema (DME) by Meta-analysis.<b>METHODS:</b> Pertinent publications were identified through systemic searches of PubMed, Medline, EMBASE, and the Cochrane Controlled Trials Register up to 30 November, 2013. Changes in central macular thickness (CMT) in μm and best-corrected visual acuity (BCVA) in logMAR equivalents were extracted at 1, 3, 6, 12 and 24mo after initial treatment, and a Meta-analysis was carried out to compare results between groups receiving IVB and MPC.<b>RESULTS:</b>Five randomized controlled trial (RCTs) and one high-quality comparative study were identified and included. Our Meta-analysis revealed that both IVB and MPC resulted in the improvements of CMT and BCVA in eyes with DME at 1mo after initial treatment, with IVB being significantly superior to MPC (<i>P</i>=0.01 and 0.02, respectively). The improvements of both measure outcomes at 3, 6, 12 and 24mo after treatment did not vary significantly between the IVB groups and MPC groups (CMT at 3mo, <i>P</i>=0.85; at 6mo, <i>P</i>=0.29; at 12mo, <i>P</i>=0.56; at 24mo, <i>P</i>=0.71; BCVA at 3mo, <i>P</i>=0.31; at 6mo, <i>P</i>= 0.30; at 12mo, <i>P</i>=0.23; at 24mo, <i>P</i>=0.52). However, the number of observed adverse events was low in all studies.<b>CONCLUSION:</b> Current evidence shows IVB treatment trends to be more effective in improvements of macular edema and vision in eyes with DME at an earlier follow up (1mo) compared with MPC. At other time, both interventions have comparable efficacy without statistical significances.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270975/intravitreal injectionbevacizumabphotocoagulationdiabetic macular edemaMeta-analysis |
| spellingShingle | Xiang-Dong Liu Xiao-Dong Zhou Zhi Wang Hong-Jie Shen Comparison of intravitreal bevacizumab with macular photocoagulation for treatment of diabetic macular edema:a systemic review and Meta-analysis International Journal of Ophthalmology intravitreal injection bevacizumab photocoagulation diabetic macular edema Meta-analysis |
| title | Comparison of intravitreal bevacizumab with macular photocoagulation for treatment of diabetic macular edema:a systemic review and Meta-analysis |
| title_full | Comparison of intravitreal bevacizumab with macular photocoagulation for treatment of diabetic macular edema:a systemic review and Meta-analysis |
| title_fullStr | Comparison of intravitreal bevacizumab with macular photocoagulation for treatment of diabetic macular edema:a systemic review and Meta-analysis |
| title_full_unstemmed | Comparison of intravitreal bevacizumab with macular photocoagulation for treatment of diabetic macular edema:a systemic review and Meta-analysis |
| title_short | Comparison of intravitreal bevacizumab with macular photocoagulation for treatment of diabetic macular edema:a systemic review and Meta-analysis |
| title_sort | comparison of intravitreal bevacizumab with macular photocoagulation for treatment of diabetic macular edema a systemic review and meta analysis |
| topic | intravitreal injection bevacizumab photocoagulation diabetic macular edema Meta-analysis |
| url | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4270975/ |
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