The relationship between depletion of brain GM1 ganglioside and Parkinson's disease
GM1 is one of the main gangliosides of the nervous system, and it exerts neurotrophic and neuroprotective properties in neurons. It is involved in many processes necessary for the correct physiology of neuronal cells. In particular, it is necessary for the activity of neuronal receptors that control...
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| Format: | Article |
| Language: | English |
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Wiley
2023-09-01
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| Series: | FEBS Open Bio |
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| Online Access: | https://doi.org/10.1002/2211-5463.13554 |
| _version_ | 1827825132331073536 |
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| author | Sandro Sonnino |
| author_facet | Sandro Sonnino |
| author_sort | Sandro Sonnino |
| collection | DOAJ |
| description | GM1 is one of the main gangliosides of the nervous system, and it exerts neurotrophic and neuroprotective properties in neurons. It is involved in many processes necessary for the correct physiology of neuronal cells. In particular, it is necessary for the activity of neuronal receptors that control processes such as differentiation, survival, and mitochondrial activity. A shortage of GM1 in the substantia nigra is potentially responsible for the neurodegeneration present in Parkinson's disease patients. In this review, I report on the role played by GM1 in neurons and how its genetic shortage may be responsible for the onset of Parkinson's disease. |
| first_indexed | 2024-03-12T02:37:48Z |
| format | Article |
| id | doaj.art-e370628fb97e4ddaaa98339dc8b32e5e |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-03-12T02:37:48Z |
| publishDate | 2023-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-e370628fb97e4ddaaa98339dc8b32e5e2023-09-04T13:56:57ZengWileyFEBS Open Bio2211-54632023-09-011391548155710.1002/2211-5463.13554The relationship between depletion of brain GM1 ganglioside and Parkinson's diseaseSandro Sonnino0Department of Medical Biotechnology and Translational Medicine University of Milan ItalyGM1 is one of the main gangliosides of the nervous system, and it exerts neurotrophic and neuroprotective properties in neurons. It is involved in many processes necessary for the correct physiology of neuronal cells. In particular, it is necessary for the activity of neuronal receptors that control processes such as differentiation, survival, and mitochondrial activity. A shortage of GM1 in the substantia nigra is potentially responsible for the neurodegeneration present in Parkinson's disease patients. In this review, I report on the role played by GM1 in neurons and how its genetic shortage may be responsible for the onset of Parkinson's disease.https://doi.org/10.1002/2211-5463.13554GFRα1‐RET‐GDNF signalingGM1 gangliosideneurodegenerationParkinson's diseaseTrkA‐NGF signalingα‐synuclein |
| spellingShingle | Sandro Sonnino The relationship between depletion of brain GM1 ganglioside and Parkinson's disease FEBS Open Bio GFRα1‐RET‐GDNF signaling GM1 ganglioside neurodegeneration Parkinson's disease TrkA‐NGF signaling α‐synuclein |
| title | The relationship between depletion of brain GM1 ganglioside and Parkinson's disease |
| title_full | The relationship between depletion of brain GM1 ganglioside and Parkinson's disease |
| title_fullStr | The relationship between depletion of brain GM1 ganglioside and Parkinson's disease |
| title_full_unstemmed | The relationship between depletion of brain GM1 ganglioside and Parkinson's disease |
| title_short | The relationship between depletion of brain GM1 ganglioside and Parkinson's disease |
| title_sort | relationship between depletion of brain gm1 ganglioside and parkinson s disease |
| topic | GFRα1‐RET‐GDNF signaling GM1 ganglioside neurodegeneration Parkinson's disease TrkA‐NGF signaling α‐synuclein |
| url | https://doi.org/10.1002/2211-5463.13554 |
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