E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis
Abstract Background The expression of programmed death-ligand 1 (PD-L1), tumor-infiltrating lymphocytes (TILs), E-cadherin, and vimentin in lung cancer tumor microenvironment is known to impact patient survival or response to therapy. The expression of these biomarkers may also differ between primar...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-06-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-10980-6 |
| _version_ | 1797795681728987136 |
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| author | Yu-Ping Chang Gong-Kai Huang Yung-Che Chen Kuo-Tung Huang Yu-Mu Chen Chiung-Yu Lin Chao-Cheng Huang Meng-Chih Lin Chin-Chou Wang |
| author_facet | Yu-Ping Chang Gong-Kai Huang Yung-Che Chen Kuo-Tung Huang Yu-Mu Chen Chiung-Yu Lin Chao-Cheng Huang Meng-Chih Lin Chin-Chou Wang |
| author_sort | Yu-Ping Chang |
| collection | DOAJ |
| description | Abstract Background The expression of programmed death-ligand 1 (PD-L1), tumor-infiltrating lymphocytes (TILs), E-cadherin, and vimentin in lung cancer tumor microenvironment is known to impact patient survival or response to therapy. The expression of these biomarkers may also differ between primary lung tumors and brain metastatic tumors. In this study, we investigated the interaction between these biomarkers in lung tumors with or without concomitant brain metastasis and the interaction with paired brain metastatic tumors. Methods The study included 48 patients with stage IV epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma. Sixteen of the forty-eight patients were diagnosed with brain metastasis, while the remaining thirty-two were not. All sixteen patients with brain metastasis had brain tumors. The expression of PD-L1, TILs (CD8+ T lymphocytes and FOXP3+ regulatory T lymphocytes), E-cadherin, and vimentin were evaluated using immunohistochemical (IHC) staining. Results Patients with brain metastasis exhibited a higher frequency of exon 19 deletion and uncommon EGFR mutations, a higher lung tumor vimentin score, worse progression-free survival (PFS), and overall survival (OS) than patients without brain metastasis. IHC staining showed no difference between paired lung and brain tumors. Patients with low PD-L1 expression had better PFS and OS. After multivariate analysis, higher body mass index, the presence of brain metastasis, bone metastasis, and uncommon EGFR mutations were correlated with worse PFS, while the presence of brain metastasis and high lung tumor E-cadherin score was associated with worse OS. Conclusions In patients with stage IV EGFR-mutant lung adenocarcinoma, high E-cadherin expression in the lung tumor might be associated with worse OS. Vimentin expression in the lung tumor was positively related to the risk of brain metastasis. |
| first_indexed | 2024-03-13T03:21:41Z |
| format | Article |
| id | doaj.art-e3708a026bef43b889e9111924a95085 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-13T03:21:41Z |
| publishDate | 2023-06-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-e3708a026bef43b889e9111924a950852023-06-25T11:19:58ZengBMCBMC Cancer1471-24072023-06-0123111110.1186/s12885-023-10980-6E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosisYu-Ping Chang0Gong-Kai Huang1Yung-Che Chen2Kuo-Tung Huang3Yu-Mu Chen4Chiung-Yu Lin5Chao-Cheng Huang6Meng-Chih Lin7Chin-Chou Wang8Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Pathology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDepartment of Pathology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of MedicineAbstract Background The expression of programmed death-ligand 1 (PD-L1), tumor-infiltrating lymphocytes (TILs), E-cadherin, and vimentin in lung cancer tumor microenvironment is known to impact patient survival or response to therapy. The expression of these biomarkers may also differ between primary lung tumors and brain metastatic tumors. In this study, we investigated the interaction between these biomarkers in lung tumors with or without concomitant brain metastasis and the interaction with paired brain metastatic tumors. Methods The study included 48 patients with stage IV epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma. Sixteen of the forty-eight patients were diagnosed with brain metastasis, while the remaining thirty-two were not. All sixteen patients with brain metastasis had brain tumors. The expression of PD-L1, TILs (CD8+ T lymphocytes and FOXP3+ regulatory T lymphocytes), E-cadherin, and vimentin were evaluated using immunohistochemical (IHC) staining. Results Patients with brain metastasis exhibited a higher frequency of exon 19 deletion and uncommon EGFR mutations, a higher lung tumor vimentin score, worse progression-free survival (PFS), and overall survival (OS) than patients without brain metastasis. IHC staining showed no difference between paired lung and brain tumors. Patients with low PD-L1 expression had better PFS and OS. After multivariate analysis, higher body mass index, the presence of brain metastasis, bone metastasis, and uncommon EGFR mutations were correlated with worse PFS, while the presence of brain metastasis and high lung tumor E-cadherin score was associated with worse OS. Conclusions In patients with stage IV EGFR-mutant lung adenocarcinoma, high E-cadherin expression in the lung tumor might be associated with worse OS. Vimentin expression in the lung tumor was positively related to the risk of brain metastasis.https://doi.org/10.1186/s12885-023-10980-6AdenocarcinomaE-cadherinEpidermal growth factor receptor (EGFR)Lung cancerProgrammed death-ligand 1 (PD-L1)Tumor-infiltrating lymphocytes |
| spellingShingle | Yu-Ping Chang Gong-Kai Huang Yung-Che Chen Kuo-Tung Huang Yu-Mu Chen Chiung-Yu Lin Chao-Cheng Huang Meng-Chih Lin Chin-Chou Wang E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis BMC Cancer Adenocarcinoma E-cadherin Epidermal growth factor receptor (EGFR) Lung cancer Programmed death-ligand 1 (PD-L1) Tumor-infiltrating lymphocytes |
| title | E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis |
| title_full | E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis |
| title_fullStr | E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis |
| title_full_unstemmed | E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis |
| title_short | E-cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor-mutant lung adenocarcinoma and the association with prognosis |
| title_sort | e cadherin expression in the tumor microenvironment of advanced epidermal growth factor receptor mutant lung adenocarcinoma and the association with prognosis |
| topic | Adenocarcinoma E-cadherin Epidermal growth factor receptor (EGFR) Lung cancer Programmed death-ligand 1 (PD-L1) Tumor-infiltrating lymphocytes |
| url | https://doi.org/10.1186/s12885-023-10980-6 |
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