Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells

Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells

Synthetic pyrrole-imidazole (PI) polyamides bind to the minor groove of double-helical DNA with high affinity and specificity, and inhibit the transcription of corresponding genes. In liver cancer, transforming growth factor (TGF)-β expression is correlated with tumor grade, and high-grade liver can...

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Bibliographic Details
Main Authors: Keiko Takagi, Yutaka Midorikawa, Tadatoshi Takayama, Hayato Abe, Kyoko Fujiwara, Masayoshi Soma, Hiroki Nagase, Toshio Miki, Noboru Fukuda
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Molecules
Subjects:
pyrrole-imidazole polyamide
TGF-β1
liver cancer
cancer stem cell
novel candidate drug
Online Access:https://www.mdpi.com/1420-3049/25/12/2883

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