A new perspective in the prevention and treatment of antitumor therapy-related cardiotoxicity: Intestinal microecology
The continuous development of antitumor therapy has significantly reduced the mortality of patients with malignancies. However, the antitumor-related cardiotoxicity has become the leading cause of long-term mortality in patients with malignancies. Besides, the pathogenesis of antitumor-related cardi...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332223013860 |
| _version_ | 1797364330632577024 |
|---|---|
| author | Chenchen Meng Xiaoming Wang Lu Fan Yajie Fan Zhipeng Yan Yunjiao Wang Yanyang Li Junping Zhang Shichao Lv |
| author_facet | Chenchen Meng Xiaoming Wang Lu Fan Yajie Fan Zhipeng Yan Yunjiao Wang Yanyang Li Junping Zhang Shichao Lv |
| author_sort | Chenchen Meng |
| collection | DOAJ |
| description | The continuous development of antitumor therapy has significantly reduced the mortality of patients with malignancies. However, the antitumor-related cardiotoxicity has become the leading cause of long-term mortality in patients with malignancies. Besides, the pathogenesis of antitumor-related cardiotoxicity is still unclear, and practical means of prevention and treatment are lacking in clinical practice. Therefore, the major challenge is how to combat the cardiotoxicity of antitumor therapy effectively. More and more studies have shown that antitumor therapy kills tumor cells while causing damage to sensitive tissues such as the intestinal mucosa, leading to the increased permeability of the intestine and the dysbiosis of intestinal microecology. In addition, the dysbiosis of intestinal microecology contributes to the development and progression of cardiovascular diseases through multiple pathways. Thus, the dysbiosis of intestinal microecology may be a potential mechanism and target for antitumor-related cardiotoxicity. We summarized the characteristics of intestinal microecology disorders induced by antitumor therapy and the association between intestinal microecological dysbiosis and CVD. And on this basis, we hypothesized the potential mechanisms of intestinal microecology mediating the occurrence of antitumor-related cardiotoxicity. Then we reviewed the previous studies targeting intestinal microecology against antitumor-associated cardiotoxicity, aiming to provide a reference for future studies on the occurrence and prevention of antitumor-related cardiotoxicity by intestinal microecology. |
| first_indexed | 2024-03-08T16:33:44Z |
| format | Article |
| id | doaj.art-e37261784c744039a83b95a65047dc36 |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-03-08T16:33:44Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-e37261784c744039a83b95a65047dc362024-01-06T04:37:34ZengElsevierBiomedicine & Pharmacotherapy0753-33222024-01-01170115588A new perspective in the prevention and treatment of antitumor therapy-related cardiotoxicity: Intestinal microecologyChenchen Meng0Xiaoming Wang1Lu Fan2Yajie Fan3Zhipeng Yan4Yunjiao Wang5Yanyang Li6Junping Zhang7Shichao Lv8First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion), Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine (National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion), Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine (National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion), Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine (National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion), Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine (National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion), Tianjin, ChinaFirst Teaching Hospital of Tianjin University of Traditional Chinese Medicine (National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion), Tianjin, ChinaDepartment of integrated Chinese and Western medicine, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; Correspondence to: Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion), Tianjin, China; Corresponding authors.First Teaching Hospital of Tianjin University of Traditional Chinese Medicine (National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion), Tianjin, China; Corresponding authors.The continuous development of antitumor therapy has significantly reduced the mortality of patients with malignancies. However, the antitumor-related cardiotoxicity has become the leading cause of long-term mortality in patients with malignancies. Besides, the pathogenesis of antitumor-related cardiotoxicity is still unclear, and practical means of prevention and treatment are lacking in clinical practice. Therefore, the major challenge is how to combat the cardiotoxicity of antitumor therapy effectively. More and more studies have shown that antitumor therapy kills tumor cells while causing damage to sensitive tissues such as the intestinal mucosa, leading to the increased permeability of the intestine and the dysbiosis of intestinal microecology. In addition, the dysbiosis of intestinal microecology contributes to the development and progression of cardiovascular diseases through multiple pathways. Thus, the dysbiosis of intestinal microecology may be a potential mechanism and target for antitumor-related cardiotoxicity. We summarized the characteristics of intestinal microecology disorders induced by antitumor therapy and the association between intestinal microecological dysbiosis and CVD. And on this basis, we hypothesized the potential mechanisms of intestinal microecology mediating the occurrence of antitumor-related cardiotoxicity. Then we reviewed the previous studies targeting intestinal microecology against antitumor-associated cardiotoxicity, aiming to provide a reference for future studies on the occurrence and prevention of antitumor-related cardiotoxicity by intestinal microecology.http://www.sciencedirect.com/science/article/pii/S0753332223013860Antitumor therapyCardiotoxicityIntestinal microecology |
| spellingShingle | Chenchen Meng Xiaoming Wang Lu Fan Yajie Fan Zhipeng Yan Yunjiao Wang Yanyang Li Junping Zhang Shichao Lv A new perspective in the prevention and treatment of antitumor therapy-related cardiotoxicity: Intestinal microecology Biomedicine & Pharmacotherapy Antitumor therapy Cardiotoxicity Intestinal microecology |
| title | A new perspective in the prevention and treatment of antitumor therapy-related cardiotoxicity: Intestinal microecology |
| title_full | A new perspective in the prevention and treatment of antitumor therapy-related cardiotoxicity: Intestinal microecology |
| title_fullStr | A new perspective in the prevention and treatment of antitumor therapy-related cardiotoxicity: Intestinal microecology |
| title_full_unstemmed | A new perspective in the prevention and treatment of antitumor therapy-related cardiotoxicity: Intestinal microecology |
| title_short | A new perspective in the prevention and treatment of antitumor therapy-related cardiotoxicity: Intestinal microecology |
| title_sort | new perspective in the prevention and treatment of antitumor therapy related cardiotoxicity intestinal microecology |
| topic | Antitumor therapy Cardiotoxicity Intestinal microecology |
| url | http://www.sciencedirect.com/science/article/pii/S0753332223013860 |
| work_keys_str_mv | AT chenchenmeng anewperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT xiaomingwang anewperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT lufan anewperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT yajiefan anewperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT zhipengyan anewperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT yunjiaowang anewperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT yanyangli anewperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT junpingzhang anewperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT shichaolv anewperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT chenchenmeng newperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT xiaomingwang newperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT lufan newperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT yajiefan newperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT zhipengyan newperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT yunjiaowang newperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT yanyangli newperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT junpingzhang newperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology AT shichaolv newperspectiveinthepreventionandtreatmentofantitumortherapyrelatedcardiotoxicityintestinalmicroecology |