Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation
The optimal antithrombotic treatment in patients receiving oral anticoagulation undergoing percutaneous coronary intervention (PCI) has been a field of intensive research. Although triple antithrombotic therapy had been, until lately, the strategy of choice, recent evidence points to the superiority...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Radcliffe Medical Media
2021-05-01
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| Series: | US Cardiology Review |
| Online Access: | https://www.uscjournal.com/articleindex/usc.2020.31 |
| _version_ | 1797200083617316864 |
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| author | Despoina-Rafailia Benetou Panayotis K Vlachakis Charalampos Varlamos Dimitrios Alexopoulos |
| author_facet | Despoina-Rafailia Benetou Panayotis K Vlachakis Charalampos Varlamos Dimitrios Alexopoulos |
| author_sort | Despoina-Rafailia Benetou |
| collection | DOAJ |
| description | The optimal antithrombotic treatment in patients receiving oral anticoagulation undergoing percutaneous coronary intervention (PCI) has been a field of intensive research. Although triple antithrombotic therapy had been, until lately, the strategy of choice, recent evidence points to the superiority of dual antithrombotic therapy regarding bleeding prevention, without significantly compromising efficacy. In the further challenging scenario of complex PCI, associated with a higher ischemic risk, the efficacy of an aspirin-free strategy, adopted shortly after the index event is under question, rendering decision-making a fairly difficult scenario for clinicians. Since patients with an indication for oral anticoagulation undergoing complex PCI are underrepresented in randomized trials, there are scarce data regarding the optimal treatment strategy in such patients. This review aims to analyze and compare different approaches regarding the type and duration of antithrombotic regimens, focusing on both safety and efficacy outcomes, as well as to discuss recent guidelines’ suggestions regarding the therapeutic approach in patients receiving oral anticoagulation undergoing PCI procedures of increased complexity. |
| first_indexed | 2024-03-07T17:41:27Z |
| format | Article |
| id | doaj.art-e373f115d45b402495e5748cca5ec0cc |
| institution | Directory Open Access Journal |
| issn | 1758-3896 1758-390X |
| language | English |
| last_indexed | 2024-04-24T07:26:01Z |
| publishDate | 2021-05-01 |
| publisher | Radcliffe Medical Media |
| record_format | Article |
| series | US Cardiology Review |
| spelling | doaj.art-e373f115d45b402495e5748cca5ec0cc2024-04-20T16:02:14ZengRadcliffe Medical MediaUS Cardiology Review1758-38961758-390X2021-05-011510.15420/usc.2020.31Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic AnticoagulationDespoina-Rafailia Benetou0Panayotis K Vlachakis1Charalampos Varlamos2Dimitrios Alexopoulos32nd Department of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, GreeceDepartment of Clinical Therapeutics, School of Medicine, National and Kapodistrian University of Athens, Alexandra General Hospital, Athens, Greece2nd Department of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece2nd Department of Cardiology, Attikon University Hospital, National and Kapodistrian University of Athens Medical School, Athens, GreeceThe optimal antithrombotic treatment in patients receiving oral anticoagulation undergoing percutaneous coronary intervention (PCI) has been a field of intensive research. Although triple antithrombotic therapy had been, until lately, the strategy of choice, recent evidence points to the superiority of dual antithrombotic therapy regarding bleeding prevention, without significantly compromising efficacy. In the further challenging scenario of complex PCI, associated with a higher ischemic risk, the efficacy of an aspirin-free strategy, adopted shortly after the index event is under question, rendering decision-making a fairly difficult scenario for clinicians. Since patients with an indication for oral anticoagulation undergoing complex PCI are underrepresented in randomized trials, there are scarce data regarding the optimal treatment strategy in such patients. This review aims to analyze and compare different approaches regarding the type and duration of antithrombotic regimens, focusing on both safety and efficacy outcomes, as well as to discuss recent guidelines’ suggestions regarding the therapeutic approach in patients receiving oral anticoagulation undergoing PCI procedures of increased complexity.https://www.uscjournal.com/articleindex/usc.2020.31 |
| spellingShingle | Despoina-Rafailia Benetou Panayotis K Vlachakis Charalampos Varlamos Dimitrios Alexopoulos Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation US Cardiology Review |
| title | Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation |
| title_full | Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation |
| title_fullStr | Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation |
| title_full_unstemmed | Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation |
| title_short | Antithrombotic Therapy in Complex Percutaneous Coronary Intervention Patients Requiring Chronic Anticoagulation |
| title_sort | antithrombotic therapy in complex percutaneous coronary intervention patients requiring chronic anticoagulation |
| url | https://www.uscjournal.com/articleindex/usc.2020.31 |
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