The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells
DNA polymerase epsilon has a critical role in DNA replication initiation. Here, the authors show that in human cancer cells POLE is dispensable for the replicative helicase assembly but not for replication initiation, which requires the non-catalytic domain of POLE1.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34911-4 |
| _version_ | 1811319618379186176 |
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| author | Sameera Vipat Dipika Gupta Sagun Jonchhe Hele Anderspuk Eli Rothenberg Tatiana N. Moiseeva |
| author_facet | Sameera Vipat Dipika Gupta Sagun Jonchhe Hele Anderspuk Eli Rothenberg Tatiana N. Moiseeva |
| author_sort | Sameera Vipat |
| collection | DOAJ |
| description | DNA polymerase epsilon has a critical role in DNA replication initiation. Here, the authors show that in human cancer cells POLE is dispensable for the replicative helicase assembly but not for replication initiation, which requires the non-catalytic domain of POLE1. |
| first_indexed | 2024-04-13T12:45:05Z |
| format | Article |
| id | doaj.art-e374e13487da4baf92fe559ec9fff4dd |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T12:45:05Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e374e13487da4baf92fe559ec9fff4dd2022-12-22T02:46:23ZengNature PortfolioNature Communications2041-17232022-11-0113111510.1038/s41467-022-34911-4The non-catalytic role of DNA polymerase epsilon in replication initiation in human cellsSameera Vipat0Dipika Gupta1Sagun Jonchhe2Hele Anderspuk3Eli Rothenberg4Tatiana N. Moiseeva5Department of Chemistry and Biotechnology, Tallinn University of TechnologyDepartment of Biochemistry and Molecular Pharmacology, New York University School of MedicineDepartment of Biochemistry and Molecular Pharmacology, New York University School of MedicineDepartment of Chemistry and Biotechnology, Tallinn University of TechnologyDepartment of Biochemistry and Molecular Pharmacology, New York University School of MedicineDepartment of Chemistry and Biotechnology, Tallinn University of TechnologyDNA polymerase epsilon has a critical role in DNA replication initiation. Here, the authors show that in human cancer cells POLE is dispensable for the replicative helicase assembly but not for replication initiation, which requires the non-catalytic domain of POLE1.https://doi.org/10.1038/s41467-022-34911-4 |
| spellingShingle | Sameera Vipat Dipika Gupta Sagun Jonchhe Hele Anderspuk Eli Rothenberg Tatiana N. Moiseeva The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells Nature Communications |
| title | The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells |
| title_full | The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells |
| title_fullStr | The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells |
| title_full_unstemmed | The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells |
| title_short | The non-catalytic role of DNA polymerase epsilon in replication initiation in human cells |
| title_sort | non catalytic role of dna polymerase epsilon in replication initiation in human cells |
| url | https://doi.org/10.1038/s41467-022-34911-4 |
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