Defining the Normal Growth Curve of Fetal Fractional Limb Volume in a Japanese Population
Fetal fractional limb volume is a useful measure for predicting birth weight and newborn adiposity; however, a normal growth curve has been reported solely in the United States. As the birth weight of neonates in Japan is significantly lower than that in the US, fetal fractional limb volume is likel...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/3/485 |
| _version_ | 1797406068557479936 |
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| author | Satoru Ikenoue Yohei Akiba Toyohide Endo Yoshifumi Kasuga Kazumi Yakubo Ryota Ishii Mamoru Tanaka Daigo Ochiai |
| author_facet | Satoru Ikenoue Yohei Akiba Toyohide Endo Yoshifumi Kasuga Kazumi Yakubo Ryota Ishii Mamoru Tanaka Daigo Ochiai |
| author_sort | Satoru Ikenoue |
| collection | DOAJ |
| description | Fetal fractional limb volume is a useful measure for predicting birth weight and newborn adiposity; however, a normal growth curve has been reported solely in the United States. As the birth weight of neonates in Japan is significantly lower than that in the US, fetal fractional limb volume is likely to be smaller in the Japanese population. This study aimed to define the normal growth curve of fractional arm volume (AVol) and thigh volume (TVol) in the Japanese population. Ultrasound scans of 453 AVol and TVol pairs were obtained; each AVol and TVol percentile at each gestational age was calculated. The measured AVol and TVol at each gestational week were also converted to z-scores based on a previous report. The growth curves increased linearly until the second trimester and exponentially in the third trimester. Linear regression showed a significant negative correlation between gestational age and AVol and TVol z-scores. The growth pattern of fetal fractional limb volume in the Japanese population is consistent with, but smaller than, that reported in the US; this difference becomes greater as the gestational age progresses. |
| first_indexed | 2024-03-09T03:19:53Z |
| format | Article |
| id | doaj.art-e375553cf4f943089b08238e26b1ff1d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T03:19:53Z |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-e375553cf4f943089b08238e26b1ff1d2023-12-03T15:12:44ZengMDPI AGJournal of Clinical Medicine2077-03832021-01-0110348510.3390/jcm10030485Defining the Normal Growth Curve of Fetal Fractional Limb Volume in a Japanese PopulationSatoru Ikenoue0Yohei Akiba1Toyohide Endo2Yoshifumi Kasuga3Kazumi Yakubo4Ryota Ishii5Mamoru Tanaka6Daigo Ochiai7Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Obstetrics and Gynecology, Saitama Municipal Hospital, Saitama 336-8522, JapanDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Obstetrics and Gynecology, Saitama Municipal Hospital, Saitama 336-8522, JapanBiostatistics Unit, Clinical and Translational Research Center, Keio University Hospital, Tokyo 160-8582, JapanDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, JapanDepartment of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, JapanFetal fractional limb volume is a useful measure for predicting birth weight and newborn adiposity; however, a normal growth curve has been reported solely in the United States. As the birth weight of neonates in Japan is significantly lower than that in the US, fetal fractional limb volume is likely to be smaller in the Japanese population. This study aimed to define the normal growth curve of fractional arm volume (AVol) and thigh volume (TVol) in the Japanese population. Ultrasound scans of 453 AVol and TVol pairs were obtained; each AVol and TVol percentile at each gestational age was calculated. The measured AVol and TVol at each gestational week were also converted to z-scores based on a previous report. The growth curves increased linearly until the second trimester and exponentially in the third trimester. Linear regression showed a significant negative correlation between gestational age and AVol and TVol z-scores. The growth pattern of fetal fractional limb volume in the Japanese population is consistent with, but smaller than, that reported in the US; this difference becomes greater as the gestational age progresses.https://www.mdpi.com/2077-0383/10/3/485fetal soft tissuefetal ultrasoundfractional arm volumefractional limb volumefractional thigh volumeJapanese population |
| spellingShingle | Satoru Ikenoue Yohei Akiba Toyohide Endo Yoshifumi Kasuga Kazumi Yakubo Ryota Ishii Mamoru Tanaka Daigo Ochiai Defining the Normal Growth Curve of Fetal Fractional Limb Volume in a Japanese Population Journal of Clinical Medicine fetal soft tissue fetal ultrasound fractional arm volume fractional limb volume fractional thigh volume Japanese population |
| title | Defining the Normal Growth Curve of Fetal Fractional Limb Volume in a Japanese Population |
| title_full | Defining the Normal Growth Curve of Fetal Fractional Limb Volume in a Japanese Population |
| title_fullStr | Defining the Normal Growth Curve of Fetal Fractional Limb Volume in a Japanese Population |
| title_full_unstemmed | Defining the Normal Growth Curve of Fetal Fractional Limb Volume in a Japanese Population |
| title_short | Defining the Normal Growth Curve of Fetal Fractional Limb Volume in a Japanese Population |
| title_sort | defining the normal growth curve of fetal fractional limb volume in a japanese population |
| topic | fetal soft tissue fetal ultrasound fractional arm volume fractional limb volume fractional thigh volume Japanese population |
| url | https://www.mdpi.com/2077-0383/10/3/485 |
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