Exosomes maintain cellular homeostasis by excreting harmful DNA from cells
The role of exosomes in intercellular communication is well established, however less in known about the biological roles of exosome secretion in exosome-secreting cells. Here the authors show that exosome secretion controls cellular homeostasis in exosome-secreting cells by removing harmful cytopla...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15287 |
| _version_ | 1818749193171238912 |
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| author | Akiko Takahashi Ryo Okada Koji Nagao Yuka Kawamata Aki Hanyu Shin Yoshimoto Masaki Takasugi Sugiko Watanabe Masato T Kanemaki Chikashi Obuse Eiji Hara |
| author_facet | Akiko Takahashi Ryo Okada Koji Nagao Yuka Kawamata Aki Hanyu Shin Yoshimoto Masaki Takasugi Sugiko Watanabe Masato T Kanemaki Chikashi Obuse Eiji Hara |
| author_sort | Akiko Takahashi |
| collection | DOAJ |
| description | The role of exosomes in intercellular communication is well established, however less in known about the biological roles of exosome secretion in exosome-secreting cells. Here the authors show that exosome secretion controls cellular homeostasis in exosome-secreting cells by removing harmful cytoplasmic DNA from cells. |
| first_indexed | 2024-12-18T03:59:53Z |
| format | Article |
| id | doaj.art-e3766fd98b5947d28ef1846c81904cc6 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-18T03:59:53Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e3766fd98b5947d28ef1846c81904cc62022-12-21T21:21:43ZengNature PortfolioNature Communications2041-17232017-05-018111610.1038/ncomms15287Exosomes maintain cellular homeostasis by excreting harmful DNA from cellsAkiko Takahashi0Ryo Okada1Koji Nagao2Yuka Kawamata3Aki Hanyu4Shin Yoshimoto5Masaki Takasugi6Sugiko Watanabe7Masato T Kanemaki8Chikashi Obuse9Eiji Hara10The Cancer Institute, Japanese Foundation for Cancer Research (JFCR)The Cancer Institute, Japanese Foundation for Cancer Research (JFCR)Graduate School of Life Science, Hokkaido UniversityThe Cancer Institute, Japanese Foundation for Cancer Research (JFCR)The Cancer Institute, Japanese Foundation for Cancer Research (JFCR)The Cancer Institute, Japanese Foundation for Cancer Research (JFCR)Department of Molecular Microbiology, Research Institute for Microbial Diseases (RIMD), Osaka UniversityDepartment of Molecular Microbiology, Research Institute for Microbial Diseases (RIMD), Osaka UniversityDivision of Molecular Cell Engineering, Department of Genetics, National Institute of Genetics, ROIS, SOKENDAIGraduate School of Life Science, Hokkaido UniversityThe Cancer Institute, Japanese Foundation for Cancer Research (JFCR)The role of exosomes in intercellular communication is well established, however less in known about the biological roles of exosome secretion in exosome-secreting cells. Here the authors show that exosome secretion controls cellular homeostasis in exosome-secreting cells by removing harmful cytoplasmic DNA from cells.https://doi.org/10.1038/ncomms15287 |
| spellingShingle | Akiko Takahashi Ryo Okada Koji Nagao Yuka Kawamata Aki Hanyu Shin Yoshimoto Masaki Takasugi Sugiko Watanabe Masato T Kanemaki Chikashi Obuse Eiji Hara Exosomes maintain cellular homeostasis by excreting harmful DNA from cells Nature Communications |
| title | Exosomes maintain cellular homeostasis by excreting harmful DNA from cells |
| title_full | Exosomes maintain cellular homeostasis by excreting harmful DNA from cells |
| title_fullStr | Exosomes maintain cellular homeostasis by excreting harmful DNA from cells |
| title_full_unstemmed | Exosomes maintain cellular homeostasis by excreting harmful DNA from cells |
| title_short | Exosomes maintain cellular homeostasis by excreting harmful DNA from cells |
| title_sort | exosomes maintain cellular homeostasis by excreting harmful dna from cells |
| url | https://doi.org/10.1038/ncomms15287 |
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