Composition of gastrointestinal microbiota in association with treatment response in individuals with metastatic castrate resistant prostate cancer progressing on enzalutamide and initiating treatment with anti-PD-1 (pembrolizumab)

Composition of gastrointestinal microbiota in association with treatment response in individuals with metastatic castrate resistant prostate cancer progressing on enzalutamide and initiating treatment with anti-PD-1 (pembrolizumab)

Recent studies in cancer patients and animal models demonstrate that intestinal microbiota influence the therapeutic efficacy of cancer treatments, including immune checkpoint inhibition. However, no studies to-date have investigated relationships between gastrointestinal microbiota composition and...

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Bibliographic Details
Main Authors: Lauren B. Peiffer, James R. White, Carli B. Jones, Rachel E. Slottke, Sarah E. Ernst, Amy E. Moran, Julie N. Graff, Karen S. Sfanos
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
16S rRNA
Microbiome
Prostate cancer
Immune checkpoint inhibition
Enzalutamide
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558622000495

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