Recent Advances of the Wiskott-aldrich Syndrome Protein Family Members in Tumorigenesis and Progression
The development of cancer is an evolving process, with proliferation, invasion and metastasis as basic biological features. As a new class of actin regulatory proteins, Wiskott-aldrich syndrome protein (WASP) family is a key component in maintaining the basic morphology of actin cytoskeleton that is...
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| Format: | Article |
| Language: | zho |
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Chinese General Practice Publishing House Co., Ltd
2022-05-01
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| Series: | Zhongguo quanke yixue |
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| Online Access: | https://www.chinagp.net/fileup/1007-9572/PDF/1649303605398-852777486.pdf |
| _version_ | 1797217202561089536 |
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| author | Xin XIE, Yan CHEN, Zhixu HE, Pei HUANG, Qinghua CHEN |
| author_facet | Xin XIE, Yan CHEN, Zhixu HE, Pei HUANG, Qinghua CHEN |
| author_sort | Xin XIE, Yan CHEN, Zhixu HE, Pei HUANG, Qinghua CHEN |
| collection | DOAJ |
| description | The development of cancer is an evolving process, with proliferation, invasion and metastasis as basic biological features. As a new class of actin regulatory proteins, Wiskott-aldrich syndrome protein (WASP) family is a key component in maintaining the basic morphology of actin cytoskeleton that is involved in many essential processes including maintaining basic structure of cells, and cell motility and signaling. It also mediates the proliferation, invasion and metastasis of cancer cells. We reviewed latest advances in the role of WASP family in cancer formation and progression, its expression levels in different cancers and related signaling pathways, suggesting that relevant research is highly promising, and reflecting the importance of WASP family in mechanisms of carcinogenesis, cancer treatment and prognosis prediction. |
| first_indexed | 2024-04-24T11:58:07Z |
| format | Article |
| id | doaj.art-e3783211fb3c43e69383c077467286e7 |
| institution | Directory Open Access Journal |
| issn | 1007-9572 |
| language | zho |
| last_indexed | 2024-04-24T11:58:07Z |
| publishDate | 2022-05-01 |
| publisher | Chinese General Practice Publishing House Co., Ltd |
| record_format | Article |
| series | Zhongguo quanke yixue |
| spelling | doaj.art-e3783211fb3c43e69383c077467286e72024-04-09T03:12:56ZzhoChinese General Practice Publishing House Co., LtdZhongguo quanke yixue1007-95722022-05-0125141779178910.12114/j.issn.1007-9572.2021.01.029Recent Advances of the Wiskott-aldrich Syndrome Protein Family Members in Tumorigenesis and ProgressionXin XIE, Yan CHEN, Zhixu HE, Pei HUANG, Qinghua CHEN0Affiliated Hospital of Zunyi Medical University/Hematology-Oncology Departmen of Guizhou Children's Hospital, Zunyi 563000, ChinaThe development of cancer is an evolving process, with proliferation, invasion and metastasis as basic biological features. As a new class of actin regulatory proteins, Wiskott-aldrich syndrome protein (WASP) family is a key component in maintaining the basic morphology of actin cytoskeleton that is involved in many essential processes including maintaining basic structure of cells, and cell motility and signaling. It also mediates the proliferation, invasion and metastasis of cancer cells. We reviewed latest advances in the role of WASP family in cancer formation and progression, its expression levels in different cancers and related signaling pathways, suggesting that relevant research is highly promising, and reflecting the importance of WASP family in mechanisms of carcinogenesis, cancer treatment and prognosis prediction.https://www.chinagp.net/fileup/1007-9572/PDF/1649303605398-852777486.pdfwasp family|wiskott-aldrich syndrome protein family|neoplasms|invasion|neoplasm metastasis|review |
| spellingShingle | Xin XIE, Yan CHEN, Zhixu HE, Pei HUANG, Qinghua CHEN Recent Advances of the Wiskott-aldrich Syndrome Protein Family Members in Tumorigenesis and Progression Zhongguo quanke yixue wasp family|wiskott-aldrich syndrome protein family|neoplasms|invasion|neoplasm metastasis|review |
| title | Recent Advances of the Wiskott-aldrich Syndrome Protein Family Members in Tumorigenesis and Progression |
| title_full | Recent Advances of the Wiskott-aldrich Syndrome Protein Family Members in Tumorigenesis and Progression |
| title_fullStr | Recent Advances of the Wiskott-aldrich Syndrome Protein Family Members in Tumorigenesis and Progression |
| title_full_unstemmed | Recent Advances of the Wiskott-aldrich Syndrome Protein Family Members in Tumorigenesis and Progression |
| title_short | Recent Advances of the Wiskott-aldrich Syndrome Protein Family Members in Tumorigenesis and Progression |
| title_sort | recent advances of the wiskott aldrich syndrome protein family members in tumorigenesis and progression |
| topic | wasp family|wiskott-aldrich syndrome protein family|neoplasms|invasion|neoplasm metastasis|review |
| url | https://www.chinagp.net/fileup/1007-9572/PDF/1649303605398-852777486.pdf |
| work_keys_str_mv | AT xinxieyanchenzhixuhepeihuangqinghuachen recentadvancesofthewiskottaldrichsyndromeproteinfamilymembersintumorigenesisandprogression |