Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys
Abstract Co‐Cr‐Mo ally (CCM) is commonly used for orthopaedic and dental implants due to its excellent mechanical properties and corrosion resistance. However, the influence of surface roughness on cell attachment and proliferation remains unclear. This study aimed to elucidate the impact of surface...
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Biosurface and Biotribology |
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| Online Access: | https://doi.org/10.1049/bsb2.12068 |
| _version_ | 1797374257207967744 |
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| author | Satoshi Migita |
| author_facet | Satoshi Migita |
| author_sort | Satoshi Migita |
| collection | DOAJ |
| description | Abstract Co‐Cr‐Mo ally (CCM) is commonly used for orthopaedic and dental implants due to its excellent mechanical properties and corrosion resistance. However, the influence of surface roughness on cell attachment and proliferation remains unclear. This study aimed to elucidate the impact of surface roughness of CCM on the attachment and proliferation of osteoblasts. CCM samples with different values of surface rouges were prepared by polishing. MC3T3‐E1 mouse osteoblasts were used for cell culture experiments. Cell attachment, morphology, and the expression of actin stress fibres, vinculin, and distribution of yes‐associated protein were analysed. Our results suggest that surface roughness does not significantly affect cell attachment and proliferation on CCM, unlike on titanium. Thus implies that other properties of CCM, such as physicochemical properties, may play a more substantial role in modulating cell behaviour. This study provides important insights into the design of CCM implants, suggesting that approaches beyond tuning surface roughness may be necessary to improve biocompatibility and osseointegration. |
| first_indexed | 2024-03-08T19:02:17Z |
| format | Article |
| id | doaj.art-e37e8cad7a104e2587509e5c304dff40 |
| institution | Directory Open Access Journal |
| issn | 2405-4518 |
| language | English |
| last_indexed | 2024-03-08T19:02:17Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Biosurface and Biotribology |
| spelling | doaj.art-e37e8cad7a104e2587509e5c304dff402023-12-28T04:57:57ZengWileyBiosurface and Biotribology2405-45182023-11-019416116810.1049/bsb2.12068Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloysSatoshi Migita0Graduate School of Science and Engineering Yamagata University Yonezawa JapanAbstract Co‐Cr‐Mo ally (CCM) is commonly used for orthopaedic and dental implants due to its excellent mechanical properties and corrosion resistance. However, the influence of surface roughness on cell attachment and proliferation remains unclear. This study aimed to elucidate the impact of surface roughness of CCM on the attachment and proliferation of osteoblasts. CCM samples with different values of surface rouges were prepared by polishing. MC3T3‐E1 mouse osteoblasts were used for cell culture experiments. Cell attachment, morphology, and the expression of actin stress fibres, vinculin, and distribution of yes‐associated protein were analysed. Our results suggest that surface roughness does not significantly affect cell attachment and proliferation on CCM, unlike on titanium. Thus implies that other properties of CCM, such as physicochemical properties, may play a more substantial role in modulating cell behaviour. This study provides important insights into the design of CCM implants, suggesting that approaches beyond tuning surface roughness may be necessary to improve biocompatibility and osseointegration.https://doi.org/10.1049/bsb2.12068biointerfacebiological reactionbiological responsebiomaterialsbiomedical applicationbiosurface |
| spellingShingle | Satoshi Migita Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys Biosurface and Biotribology biointerface biological reaction biological response biomaterials biomedical application biosurface |
| title | Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys |
| title_full | Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys |
| title_fullStr | Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys |
| title_full_unstemmed | Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys |
| title_short | Surface roughness and its role in mediating cell adhesion on cobalt‐chromium‐molybdenum alloys |
| title_sort | surface roughness and its role in mediating cell adhesion on cobalt chromium molybdenum alloys |
| topic | biointerface biological reaction biological response biomaterials biomedical application biosurface |
| url | https://doi.org/10.1049/bsb2.12068 |
| work_keys_str_mv | AT satoshimigita surfaceroughnessanditsroleinmediatingcelladhesiononcobaltchromiummolybdenumalloys |