PLC-γ-Ca2+ pathway regulates axonal TrkB endocytosis and is required for long-distance propagation of BDNF signaling

PLC-γ-Ca2+ pathway regulates axonal TrkB endocytosis and is required for long-distance propagation of BDNF signaling

Brain-derived neurotrophic factor (BDNF) and its tropomyosin receptor kinase B (TrkB) are important signaling proteins that regulate dendritic growth and maintenance in the central nervous system (CNS). After binding of BDNF, TrkB is endocytosed into endosomes and continues signaling within the cell...

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Bibliographic Details
Main Authors: Guillermo Moya-Alvarado, Xavier Valero-Peña, Alejandro Aguirre-Soto, Fernando J. Bustos, Oscar M. Lazo, Francisca C. Bronfman
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
PLC-γ
brain-derived neurotrophic factor
TrkB
axonal transport
signaling endosomes
dendritic branching
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1009404/full

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