"Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges."
Exposure to toxic metals poses a serious human health hazard based on ubiquitous environmental presence, the extent of exposure, and the toxicity and disease states associated with exposure. This global health issue warrants accurate and reliable models derived from the risk assessment process to pr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00201/full |
| _version_ | 1811232627208749056 |
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| author | Paul eRay Paul eRay Andrew eYosim Rebecca eFry Rebecca eFry |
| author_facet | Paul eRay Paul eRay Andrew eYosim Rebecca eFry Rebecca eFry |
| author_sort | Paul eRay |
| collection | DOAJ |
| description | Exposure to toxic metals poses a serious human health hazard based on ubiquitous environmental presence, the extent of exposure, and the toxicity and disease states associated with exposure. This global health issue warrants accurate and reliable models derived from the risk assessment process to predict disease risk in populations. There has been considerable interest recently in the impact of environmental toxicants such as toxic metals on the epigenome. Epigenetic modifications are somatically inherited alterations to an individual’s genome without a change in the DNA sequence, and include, but are not limited to, three commonly studied alterations: DNA methylation, histone modification, and non-coding RNA expression. Given the role of epigenetic alterations in regulating gene and thus protein expression, there is the potential for the integration of toxic metal-induced epigenetic alterations as informative factors in the risk assessment process. In the present review, epigenetic alterations induced by five high priority toxic metals/metalloids are prioritized for analysis and their possible inclusion into the risk assessment process is discussed. |
| first_indexed | 2024-04-12T11:06:05Z |
| format | Article |
| id | doaj.art-e3816e44a04e4a8292f453d9ddd981b6 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-12T11:06:05Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-e3816e44a04e4a8292f453d9ddd981b62022-12-22T03:35:46ZengFrontiers Media S.A.Frontiers in Genetics1664-80212014-07-01510.3389/fgene.2014.0020194858"Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges."Paul eRay0Paul eRay1Andrew eYosim2Rebecca eFry3Rebecca eFry4University of North Carolina Chapel HillUniversity of North Carolina at Chapel HillUniversity of North Carolina Chapel HillUniversity of North Carolina Chapel HillUniversity of North Carolina at Chapel HillExposure to toxic metals poses a serious human health hazard based on ubiquitous environmental presence, the extent of exposure, and the toxicity and disease states associated with exposure. This global health issue warrants accurate and reliable models derived from the risk assessment process to predict disease risk in populations. There has been considerable interest recently in the impact of environmental toxicants such as toxic metals on the epigenome. Epigenetic modifications are somatically inherited alterations to an individual’s genome without a change in the DNA sequence, and include, but are not limited to, three commonly studied alterations: DNA methylation, histone modification, and non-coding RNA expression. Given the role of epigenetic alterations in regulating gene and thus protein expression, there is the potential for the integration of toxic metal-induced epigenetic alterations as informative factors in the risk assessment process. In the present review, epigenetic alterations induced by five high priority toxic metals/metalloids are prioritized for analysis and their possible inclusion into the risk assessment process is discussed.http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00201/fullDiseaseDNA MethylationEpigenomicsRisk AssessmentepigeneticsmiRNA |
| spellingShingle | Paul eRay Paul eRay Andrew eYosim Rebecca eFry Rebecca eFry "Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges." Frontiers in Genetics Disease DNA Methylation Epigenomics Risk Assessment epigenetics miRNA |
| title | "Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges." |
| title_full | "Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges." |
| title_fullStr | "Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges." |
| title_full_unstemmed | "Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges." |
| title_short | "Incorporating epigenetic data into the risk assessment process for the toxic metals arsenic, cadmium, chromium, lead, and mercury: strategies and challenges." |
| title_sort | quot incorporating epigenetic data into the risk assessment process for the toxic metals arsenic cadmium chromium lead and mercury strategies and challenges quot |
| topic | Disease DNA Methylation Epigenomics Risk Assessment epigenetics miRNA |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00201/full |
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