Knockdown of TRPM7 attenuates apoptosis and inflammation in neonatal necrotizing enterocolitis model cell IEC-6 via modulating TLR4/NF-κB and MEK/ERK pathways

Knockdown of TRPM7 attenuates apoptosis and inflammation in neonatal necrotizing enterocolitis model cell IEC-6 via modulating TLR4/NF-κB and MEK/ERK pathways

Objective(s): Neonatal necrotizing enterocolitis (NEC) is the most common gastrointestinal critical illness in neonatal infants. TRPM7 reportedly plays a role in human inflammatory bowel disease (IBD) and colorectal cancer, but the role of TRPM7 in the pathogenesis of NEC remains vague.Materials and...

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Bibliographic Details
Main Authors: Qi Wang, Lu An, Juan Li, Bing Liu, Junpeng Hui, Qiang Zhang, Xin Zhang
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2022-08-01
Series:Iranian Journal of Basic Medical Sciences
Subjects:
apoptosis
inflammation
necrotizing enterocolitis
trpm7
viability
Online Access:https://ijbms.mums.ac.ir/article_20669_29e5c6e8bdc69a0405583ce833702619.pdf

Internet

https://ijbms.mums.ac.ir/article_20669_29e5c6e8bdc69a0405583ce833702619.pdf

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