A review of the clinical introduction of 4D particle therapy research concepts
Background and purpose: Many 4D particle therapy research concepts have been recently translated into clinics, however, remaining substantial differences depend on the indication and institute-related aspects. This work aims to summarise current state-of-the-art 4D particle therapy technology and ou...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Physics and Imaging in Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405631624000058 |
| _version_ | 1827311160649580544 |
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| author | Barbara Knäusl Gabriele Belotti Jenny Bertholet Juliane Daartz Stella Flampouri Mischa Hoogeman Antje C Knopf Haibo Lin Astrid Moerman Chiara Paganelli Antoni Rucinski Reinhard Schulte Shing Shimizu Kristin Stützer Xiaodong Zhang Ye Zhang Katarzyna Czerska |
| author_facet | Barbara Knäusl Gabriele Belotti Jenny Bertholet Juliane Daartz Stella Flampouri Mischa Hoogeman Antje C Knopf Haibo Lin Astrid Moerman Chiara Paganelli Antoni Rucinski Reinhard Schulte Shing Shimizu Kristin Stützer Xiaodong Zhang Ye Zhang Katarzyna Czerska |
| author_sort | Barbara Knäusl |
| collection | DOAJ |
| description | Background and purpose: Many 4D particle therapy research concepts have been recently translated into clinics, however, remaining substantial differences depend on the indication and institute-related aspects. This work aims to summarise current state-of-the-art 4D particle therapy technology and outline a roadmap for future research and developments. Material and methods: This review focused on the clinical implementation of 4D approaches for imaging, treatment planning, delivery and evaluation based on the 2021 and 2022 4D Treatment Workshops for Particle Therapy as well as a review of the most recent surveys, guidelines and scientific papers dedicated to this topic. Results: Available technological capabilities for motion surveillance and compensation determined the course of each 4D particle treatment. 4D motion management, delivery techniques and strategies including imaging were diverse and depended on many factors. These included aspects of motion amplitude, tumour location, as well as accelerator technology driving the necessity of centre-specific dosimetric validation. Novel methodologies for X-ray based image processing and MRI for real-time tumour tracking and motion management were shown to have a large potential for online and offline adaptation schemes compensating for potential anatomical changes over the treatment course. The latest research developments were dominated by particle imaging, artificial intelligence methods and FLASH adding another level of complexity but also opportunities in the context of 4D treatments. Conclusion: This review showed that the rapid technological advances in radiation oncology together with the available intrafractional motion management and adaptive strategies paved the way towards clinical implementation. |
| first_indexed | 2024-03-08T13:02:42Z |
| format | Article |
| id | doaj.art-e3839c68deee40f5962c67d5dfa7d2e6 |
| institution | Directory Open Access Journal |
| issn | 2405-6316 |
| language | English |
| last_indexed | 2024-04-24T20:13:39Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Physics and Imaging in Radiation Oncology |
| spelling | doaj.art-e3839c68deee40f5962c67d5dfa7d2e62024-03-23T06:25:00ZengElsevierPhysics and Imaging in Radiation Oncology2405-63162024-01-0129100535A review of the clinical introduction of 4D particle therapy research conceptsBarbara Knäusl0Gabriele Belotti1Jenny Bertholet2Juliane Daartz3Stella Flampouri4Mischa Hoogeman5Antje C Knopf6Haibo Lin7Astrid Moerman8Chiara Paganelli9Antoni Rucinski10Reinhard Schulte11Shing Shimizu12Kristin Stützer13Xiaodong Zhang14Ye Zhang15Katarzyna Czerska16Department of Radiation Oncology, Medical University of Vienna, Vienna, Austria; Corresponding author.Department of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, ItalyDivision of Medical Radiation Physics and Department of Radiation Oncology, Inselspital, Bern University Hospital, and University of Bern, Bern, SwitzerlandDepartment of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USAEmory University, Radiation Oncology, Atlanta, USADepartment of Medical Physics & Informatics, HollandPTC, Delft, The Netherlands; Erasmus MC Cancer Institute, University Medical Center Rotterdam, Department of Radiotherapy, Rotterdam, The NetherlandsInstitut für Medizintechnik und Medizininformatik Hochschule für Life Sciences FHNW, Muttenz, SwitzerlandNew York Proton Center, New York, NY, USADepartment of Medical Physics & Informatics, HollandPTC, Delft, The NetherlandsDepartment of Electronics, Information and Bioengineering, Politecnico di Milano, Milano, ItalyInstitute of Nuclear Physics Polish Academy of Sciences, PL-31342 Krakow, PolandDivision of Biomedical Engineering Sciences, School of Medicine, Loma Linda UniversityDepartment of Carbon Ion Radiotherapy, Osaka University Graduate School of Medicine, Osaka, JapanOncoRay – National Center for Radiation Research in Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany; Helmholtz-Zentrum Dresden – Rossendorf, Institute of Radiooncology – OncoRay, Dresden, GermanyDepartment of Radiation Physics, Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USACenter for Proton Therapy, Paul Scherrer Institute, Villigen PSI, SwitzerlandCenter for Proton Therapy, Paul Scherrer Institute, Villigen PSI, SwitzerlandBackground and purpose: Many 4D particle therapy research concepts have been recently translated into clinics, however, remaining substantial differences depend on the indication and institute-related aspects. This work aims to summarise current state-of-the-art 4D particle therapy technology and outline a roadmap for future research and developments. Material and methods: This review focused on the clinical implementation of 4D approaches for imaging, treatment planning, delivery and evaluation based on the 2021 and 2022 4D Treatment Workshops for Particle Therapy as well as a review of the most recent surveys, guidelines and scientific papers dedicated to this topic. Results: Available technological capabilities for motion surveillance and compensation determined the course of each 4D particle treatment. 4D motion management, delivery techniques and strategies including imaging were diverse and depended on many factors. These included aspects of motion amplitude, tumour location, as well as accelerator technology driving the necessity of centre-specific dosimetric validation. Novel methodologies for X-ray based image processing and MRI for real-time tumour tracking and motion management were shown to have a large potential for online and offline adaptation schemes compensating for potential anatomical changes over the treatment course. The latest research developments were dominated by particle imaging, artificial intelligence methods and FLASH adding another level of complexity but also opportunities in the context of 4D treatments. Conclusion: This review showed that the rapid technological advances in radiation oncology together with the available intrafractional motion management and adaptive strategies paved the way towards clinical implementation.http://www.sciencedirect.com/science/article/pii/S2405631624000058Intrafractional motionParticle therapyMotion management4D imagingAdaptive workflows4D Treatment Workshop for Particle Therapy |
| spellingShingle | Barbara Knäusl Gabriele Belotti Jenny Bertholet Juliane Daartz Stella Flampouri Mischa Hoogeman Antje C Knopf Haibo Lin Astrid Moerman Chiara Paganelli Antoni Rucinski Reinhard Schulte Shing Shimizu Kristin Stützer Xiaodong Zhang Ye Zhang Katarzyna Czerska A review of the clinical introduction of 4D particle therapy research concepts Physics and Imaging in Radiation Oncology Intrafractional motion Particle therapy Motion management 4D imaging Adaptive workflows 4D Treatment Workshop for Particle Therapy |
| title | A review of the clinical introduction of 4D particle therapy research concepts |
| title_full | A review of the clinical introduction of 4D particle therapy research concepts |
| title_fullStr | A review of the clinical introduction of 4D particle therapy research concepts |
| title_full_unstemmed | A review of the clinical introduction of 4D particle therapy research concepts |
| title_short | A review of the clinical introduction of 4D particle therapy research concepts |
| title_sort | review of the clinical introduction of 4d particle therapy research concepts |
| topic | Intrafractional motion Particle therapy Motion management 4D imaging Adaptive workflows 4D Treatment Workshop for Particle Therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2405631624000058 |
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