Application of metabolomics in osteoporosis research
Osteoporosis (OP) is a systemic disease characterized by bone metabolism imbalance and bone microstructure destruction, which causes serious social and economic burden. At present, the diagnosis and treatment of OP mainly rely on imaging combined with drugs. However, the existing pathogenic mechanis...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.993253/full |
| _version_ | 1797989061176066048 |
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| author | Zhenyu Zhao Zhenyu Zhao Zhengwei Cai Aopan Chen Ming Cai Kai Yang |
| author_facet | Zhenyu Zhao Zhenyu Zhao Zhengwei Cai Aopan Chen Ming Cai Kai Yang |
| author_sort | Zhenyu Zhao |
| collection | DOAJ |
| description | Osteoporosis (OP) is a systemic disease characterized by bone metabolism imbalance and bone microstructure destruction, which causes serious social and economic burden. At present, the diagnosis and treatment of OP mainly rely on imaging combined with drugs. However, the existing pathogenic mechanisms, diagnosis and treatment strategies for OP are not clear and effective enough, and the disease progression that cannot reflect OP further restricts its effective treatment. The application of metabolomics has facilitated the study of OP, further exploring the mechanism and behavior of bone cells, prevention, and treatment of the disease from various metabolic perspectives, finally realizing the possibility of a holistic approach. In this review, we focus on the application of metabolomics in OP research, especially the newer systematic application of metabolomics and treatment with herbal medicine and their extracts. In addition, the prospects of clinical transformation in related fields are also discussed. The aim of this study is to highlight the use of metabolomics in OP research, especially in exploring the pathogenesis of OP and the therapeutic mechanisms of natural herbal medicine, for the benefit of interdisciplinary researchers including clinicians, biologists, and materials engineers. |
| first_indexed | 2024-04-11T08:14:14Z |
| format | Article |
| id | doaj.art-e38491faacde4a77b71049eb8cfab62e |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T08:14:14Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-e38491faacde4a77b71049eb8cfab62e2022-12-22T04:35:14ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.993253993253Application of metabolomics in osteoporosis researchZhenyu Zhao0Zhenyu Zhao1Zhengwei Cai2Aopan Chen3Ming Cai4Kai Yang5Department of Orthopaedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaShanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Orthopaedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Orthopaedics, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, ChinaShanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaOsteoporosis (OP) is a systemic disease characterized by bone metabolism imbalance and bone microstructure destruction, which causes serious social and economic burden. At present, the diagnosis and treatment of OP mainly rely on imaging combined with drugs. However, the existing pathogenic mechanisms, diagnosis and treatment strategies for OP are not clear and effective enough, and the disease progression that cannot reflect OP further restricts its effective treatment. The application of metabolomics has facilitated the study of OP, further exploring the mechanism and behavior of bone cells, prevention, and treatment of the disease from various metabolic perspectives, finally realizing the possibility of a holistic approach. In this review, we focus on the application of metabolomics in OP research, especially the newer systematic application of metabolomics and treatment with herbal medicine and their extracts. In addition, the prospects of clinical transformation in related fields are also discussed. The aim of this study is to highlight the use of metabolomics in OP research, especially in exploring the pathogenesis of OP and the therapeutic mechanisms of natural herbal medicine, for the benefit of interdisciplinary researchers including clinicians, biologists, and materials engineers.https://www.frontiersin.org/articles/10.3389/fendo.2022.993253/fullmetabolomicsosteoporosispathogenic mechanismherbal medicinetreatment |
| spellingShingle | Zhenyu Zhao Zhenyu Zhao Zhengwei Cai Aopan Chen Ming Cai Kai Yang Application of metabolomics in osteoporosis research Frontiers in Endocrinology metabolomics osteoporosis pathogenic mechanism herbal medicine treatment |
| title | Application of metabolomics in osteoporosis research |
| title_full | Application of metabolomics in osteoporosis research |
| title_fullStr | Application of metabolomics in osteoporosis research |
| title_full_unstemmed | Application of metabolomics in osteoporosis research |
| title_short | Application of metabolomics in osteoporosis research |
| title_sort | application of metabolomics in osteoporosis research |
| topic | metabolomics osteoporosis pathogenic mechanism herbal medicine treatment |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.993253/full |
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