Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia
Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disease (ND) with a high mortality rate. Symptomatic treatment is the only clinically adopted treatment. However, it has poor effect and serious complications. Traditional diagnostic methods [such as magnetic resonance imaging (...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Molecular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2022.1043947/full |
| _version_ | 1811342027485347840 |
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| author | Yingying Ding Yingying Ding Yong Zhang Xuehong Liu |
| author_facet | Yingying Ding Yingying Ding Yong Zhang Xuehong Liu |
| author_sort | Yingying Ding |
| collection | DOAJ |
| description | Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disease (ND) with a high mortality rate. Symptomatic treatment is the only clinically adopted treatment. However, it has poor effect and serious complications. Traditional diagnostic methods [such as magnetic resonance imaging (MRI)] have drawbacks. Presently, the superiority of RNA interference (RNAi) and extracellular vesicles (EVs) in improving SCA has attracted extensive attention. Both can serve as the potential biomarkers for the diagnosing and monitoring disease progression. Herein, we analyzed the basis and prospect of therapies for SCA. Meanwhile, we elaborated the development and application of miRNAs, siRNAs, shRNAs, and EVs in the diagnosis and treatment of SCA. We propose the combination of RNAi and EVs to avoid the adverse factors of their respective treatment and maximize the benefits of treatment through the technology of EVs loaded with RNA. Obviously, the combinational therapy of RNAi and EVs may more accurately diagnose and cure SCA. |
| first_indexed | 2024-04-13T19:04:08Z |
| format | Article |
| id | doaj.art-e3856c54c8114629bb03f4acf0af3efb |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-13T19:04:08Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-e3856c54c8114629bb03f4acf0af3efb2022-12-22T02:34:02ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992022-10-011510.3389/fnmol.2022.10439471043947Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxiaYingying Ding0Yingying Ding1Yong Zhang2Xuehong Liu3Department of Histology and Embryology, Medical College, Shaoxing University, Shaoxing, Zhejiang, ChinaDepartment of Clinical Medicine, Affiliated Hospital of Hangzhou Normal University, Hangzhou, ChinaDepartment of Histology and Embryology, Medical College, Shaoxing University, Shaoxing, Zhejiang, ChinaDepartment of Histology and Embryology, Medical College, Shaoxing University, Shaoxing, Zhejiang, ChinaSpinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disease (ND) with a high mortality rate. Symptomatic treatment is the only clinically adopted treatment. However, it has poor effect and serious complications. Traditional diagnostic methods [such as magnetic resonance imaging (MRI)] have drawbacks. Presently, the superiority of RNA interference (RNAi) and extracellular vesicles (EVs) in improving SCA has attracted extensive attention. Both can serve as the potential biomarkers for the diagnosing and monitoring disease progression. Herein, we analyzed the basis and prospect of therapies for SCA. Meanwhile, we elaborated the development and application of miRNAs, siRNAs, shRNAs, and EVs in the diagnosis and treatment of SCA. We propose the combination of RNAi and EVs to avoid the adverse factors of their respective treatment and maximize the benefits of treatment through the technology of EVs loaded with RNA. Obviously, the combinational therapy of RNAi and EVs may more accurately diagnose and cure SCA.https://www.frontiersin.org/articles/10.3389/fnmol.2022.1043947/fullextracellular vesicleRNA interferencemiRNAsiRNAshRNAspinocerebellar ataxia |
| spellingShingle | Yingying Ding Yingying Ding Yong Zhang Xuehong Liu Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia Frontiers in Molecular Neuroscience extracellular vesicle RNA interference miRNA siRNA shRNA spinocerebellar ataxia |
| title | Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia |
| title_full | Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia |
| title_fullStr | Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia |
| title_full_unstemmed | Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia |
| title_short | Combinational treatments of RNA interference and extracellular vesicles in the spinocerebellar ataxia |
| title_sort | combinational treatments of rna interference and extracellular vesicles in the spinocerebellar ataxia |
| topic | extracellular vesicle RNA interference miRNA siRNA shRNA spinocerebellar ataxia |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2022.1043947/full |
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