ABCB1 4036A>G and 1236C>T polymorphisms affect plasma efavirenz levels in South African HIV/AIDS patients

ABCB1 4036A>G and 1236C>T polymorphisms affect plasma efavirenz levels in South African HIV/AIDS patients

Abstract The ABCB1 gene encodes P-glycoprotein, an ATP-dependent drug efflux pump, which is responsible for drug transport across extra- and intra-cellular membranes. The variability in the expression of ABCB1 may contribute to variable plasma efavirenz concentration which results in variability in...

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Bibliographic Details
Main Authors: Marelize eSwart, Yuan eRen, Peter eSmith, Collet eDandara
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-11-01
Series:Frontiers in Genetics
Subjects:
South Africa
hiv/aids
drug metabolism
ABCB1 polymorphisms
efavirenz pharmacogenetics
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2012.00236/full

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