LncRNA MAFG-AS1 is involved in human cancer progression
Abstract Long noncoding RNAs (lncRNAs) refer to a type of non-protein-coding transcript of more than 200 nucleotides. LncRNAs play fundamental roles in disease development and progression, and lncRNAs are dysregulated in many pathophysiological processes. Thus, lncRNAs may have potential value in cl...
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01486-9 |
| _version_ | 1797630413074595840 |
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| author | Penghui Li Xiao Ma Xinyu Gu |
| author_facet | Penghui Li Xiao Ma Xinyu Gu |
| author_sort | Penghui Li |
| collection | DOAJ |
| description | Abstract Long noncoding RNAs (lncRNAs) refer to a type of non-protein-coding transcript of more than 200 nucleotides. LncRNAs play fundamental roles in disease development and progression, and lncRNAs are dysregulated in many pathophysiological processes. Thus, lncRNAs may have potential value in clinical applications. The lncRNA, MAF BZIP Transcription Factor G (MAFG)-AS1, is dysregulated in several cancer, including breast cancer, lung cancer, liver cancer, bladder cancer, colorectal cancer, gastric cancer, esophagus cancer, prostate cancer, pancreatic cancer, ovarian cancer, and glioma. Altered MAFG-AS1 levels are also associated with diverse clinical characteristics and patient outcomes. Mechanistically, MAFG-AS1 mediates a variety of cellular processes via the regulation of target gene expression. Therefore, the diagnostic, prognostic, and therapeutic aspects of MAFG-AS1 have been widely explored. In this review, we discuss the expression, major roles, and molecular mechanisms of MAFG-AS1, the relationship between MAFG-AS1 and clinical features of diseases, and the clinical applications of MAFG-AS1. |
| first_indexed | 2024-03-11T11:06:59Z |
| format | Article |
| id | doaj.art-e385e7d2b8b84585a584598f1d575cbf |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-11T11:06:59Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-e385e7d2b8b84585a584598f1d575cbf2023-11-12T12:10:48ZengBMCEuropean Journal of Medical Research2047-783X2023-11-012811810.1186/s40001-023-01486-9LncRNA MAFG-AS1 is involved in human cancer progressionPenghui Li0Xiao Ma1Xinyu Gu2Department of Oncology, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyZhejiang University School of MedicineDepartment of Oncology, The First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and TechnologyAbstract Long noncoding RNAs (lncRNAs) refer to a type of non-protein-coding transcript of more than 200 nucleotides. LncRNAs play fundamental roles in disease development and progression, and lncRNAs are dysregulated in many pathophysiological processes. Thus, lncRNAs may have potential value in clinical applications. The lncRNA, MAF BZIP Transcription Factor G (MAFG)-AS1, is dysregulated in several cancer, including breast cancer, lung cancer, liver cancer, bladder cancer, colorectal cancer, gastric cancer, esophagus cancer, prostate cancer, pancreatic cancer, ovarian cancer, and glioma. Altered MAFG-AS1 levels are also associated with diverse clinical characteristics and patient outcomes. Mechanistically, MAFG-AS1 mediates a variety of cellular processes via the regulation of target gene expression. Therefore, the diagnostic, prognostic, and therapeutic aspects of MAFG-AS1 have been widely explored. In this review, we discuss the expression, major roles, and molecular mechanisms of MAFG-AS1, the relationship between MAFG-AS1 and clinical features of diseases, and the clinical applications of MAFG-AS1.https://doi.org/10.1186/s40001-023-01486-9lncRNAMAFG-AS1CancerExpressionFunction |
| spellingShingle | Penghui Li Xiao Ma Xinyu Gu LncRNA MAFG-AS1 is involved in human cancer progression European Journal of Medical Research lncRNA MAFG-AS1 Cancer Expression Function |
| title | LncRNA MAFG-AS1 is involved in human cancer progression |
| title_full | LncRNA MAFG-AS1 is involved in human cancer progression |
| title_fullStr | LncRNA MAFG-AS1 is involved in human cancer progression |
| title_full_unstemmed | LncRNA MAFG-AS1 is involved in human cancer progression |
| title_short | LncRNA MAFG-AS1 is involved in human cancer progression |
| title_sort | lncrna mafg as1 is involved in human cancer progression |
| topic | lncRNA MAFG-AS1 Cancer Expression Function |
| url | https://doi.org/10.1186/s40001-023-01486-9 |
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