Hashimoto's encephalopathy: Report of three cases
Both severe thyrotoxicosis and hypothyroidism may affect brain function and cause a change in consciousness, as seen with a thyroid storm or myxedema coma. However, encephalopathy may also develop in patients with autoimmune thyroid diseases independent of actual thyroid function level, and this is...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2014-11-01
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| Series: | Journal of the Formosan Medical Association |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0929664612000642 |
| _version_ | 1828760568372133888 |
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| author | Jan-Shun Chang Tien-Chun Chang |
| author_facet | Jan-Shun Chang Tien-Chun Chang |
| author_sort | Jan-Shun Chang |
| collection | DOAJ |
| description | Both severe thyrotoxicosis and hypothyroidism may affect brain function and cause a change in consciousness, as seen with a thyroid storm or myxedema coma. However, encephalopathy may also develop in patients with autoimmune thyroid diseases independent of actual thyroid function level, and this is known as Hashimoto's encephalopathy. Although most patients are found to have Hashimoto's thyroiditis, less frequently they have Graves' disease. Clinical manifestations include epilepsy, disturbance of consciousness, cognitive impairment, memory loss, myoclonus, hallucinations, stroke-like episodes, tremor, involuntary movements, language impairment, and gait impairment. Hashimoto's encephalopathy is a relatively rare disease. As a good response can be obtained with corticosteroid therapy, early diagnosis and treatment is very beneficial for patients. Here we report three patients with Hashimoto's encephalopathy with typical manifestations of hallucinations that were associated with hypothyroidism, hyperthyroidism, and euthyroid status, respectively. They all showed a dramatic response to methylprednisolone pulse therapy. |
| first_indexed | 2024-12-11T01:16:02Z |
| format | Article |
| id | doaj.art-e38665fdd8a84199b41bd0aa13f9a750 |
| institution | Directory Open Access Journal |
| issn | 0929-6646 |
| language | English |
| last_indexed | 2024-12-11T01:16:02Z |
| publishDate | 2014-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj.art-e38665fdd8a84199b41bd0aa13f9a7502022-12-22T01:25:52ZengElsevierJournal of the Formosan Medical Association0929-66462014-11-011131186286610.1016/j.jfma.2011.05.012Hashimoto's encephalopathy: Report of three casesJan-Shun Chang0Tien-Chun Chang1Department of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanDepartment of Internal Medicine, National Taiwan University Hospital, Taipei, TaiwanBoth severe thyrotoxicosis and hypothyroidism may affect brain function and cause a change in consciousness, as seen with a thyroid storm or myxedema coma. However, encephalopathy may also develop in patients with autoimmune thyroid diseases independent of actual thyroid function level, and this is known as Hashimoto's encephalopathy. Although most patients are found to have Hashimoto's thyroiditis, less frequently they have Graves' disease. Clinical manifestations include epilepsy, disturbance of consciousness, cognitive impairment, memory loss, myoclonus, hallucinations, stroke-like episodes, tremor, involuntary movements, language impairment, and gait impairment. Hashimoto's encephalopathy is a relatively rare disease. As a good response can be obtained with corticosteroid therapy, early diagnosis and treatment is very beneficial for patients. Here we report three patients with Hashimoto's encephalopathy with typical manifestations of hallucinations that were associated with hypothyroidism, hyperthyroidism, and euthyroid status, respectively. They all showed a dramatic response to methylprednisolone pulse therapy.http://www.sciencedirect.com/science/article/pii/S0929664612000642autoimmune thyroiditisencephalopathyhallucinationsHashimoto's thyroiditissteroids |
| spellingShingle | Jan-Shun Chang Tien-Chun Chang Hashimoto's encephalopathy: Report of three cases Journal of the Formosan Medical Association autoimmune thyroiditis encephalopathy hallucinations Hashimoto's thyroiditis steroids |
| title | Hashimoto's encephalopathy: Report of three cases |
| title_full | Hashimoto's encephalopathy: Report of three cases |
| title_fullStr | Hashimoto's encephalopathy: Report of three cases |
| title_full_unstemmed | Hashimoto's encephalopathy: Report of three cases |
| title_short | Hashimoto's encephalopathy: Report of three cases |
| title_sort | hashimoto s encephalopathy report of three cases |
| topic | autoimmune thyroiditis encephalopathy hallucinations Hashimoto's thyroiditis steroids |
| url | http://www.sciencedirect.com/science/article/pii/S0929664612000642 |
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