Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients
In order to optimize the therapy, the functional state of the pancreas (P) and the peculiarities of metabolic activity of intestinal microbiota in adults with cystic fibrosis (CF) were assessed. Materials and methods. 14 CF patients (20-34 years, 7 men, 7 women) were enrolled. In 8 patients, the dia...
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2018-10-01
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| Series: | Терапевтический архив |
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| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32894/pdf |
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| author | L V Vinokurova G E Baimakanova S A Krasovsky S Yu Silvestrova E A Dubtsova G G Varvanina D S Bordin |
| author_facet | L V Vinokurova G E Baimakanova S A Krasovsky S Yu Silvestrova E A Dubtsova G G Varvanina D S Bordin |
| author_sort | L V Vinokurova |
| collection | DOAJ |
| description | In order to optimize the therapy, the functional state of the pancreas (P) and the peculiarities of metabolic activity of intestinal microbiota in adults with cystic fibrosis (CF) were assessed. Materials and methods. 14 CF patients (20-34 years, 7 men, 7 women) were enrolled. In 8 patients, the diagnosis was confirmed in the first year of life on the basis of clinical data, positive sweat test, 5 had genetic confirmation. In 4 patients, the diagnosis was confirmed at the age of 8-13 years and 2 patients aged 18, 27 years. In this group, genetic confirmation was in 4 subjects. In addition to general clinical studies, the level of C-peptide in blood, elastase and the concentration of short chain fatty acids in feces was determined. Results and discussion. Of elastase feces in 9 patients was 5.5±4.7 icg/g, that is revealed severe exocrine insufficiency of the pancreas and in 5 patients the elastase level was normal and amounted to 402±124 icg/g. Deployed the clinical picture of diabetes mellitus was observed in 3 patients. Metabolic activity of the colon microflora as a whole was reduced, the sum of the concentration of short-chain fatty acids (ΣCn) was 6.03±4.11 mg/g at a rate of 10.61±5.11 (p |
| first_indexed | 2024-12-13T01:33:27Z |
| format | Article |
| id | doaj.art-e387a1ee1ace4d39a342b13818f035b0 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T01:33:27Z |
| publishDate | 2018-10-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-e387a1ee1ace4d39a342b13818f035b02022-12-22T00:03:57Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422018-10-019010848810.26442/terarkh201890104-8829645Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patientsL V Vinokurova0G E Baimakanova1S A Krasovsky2S Yu Silvestrova3E A Dubtsova4G G Varvanina5D S Bordin6A.S.Loginov Moscow Clinical Scientific Center, Moscow Healthcare DepartmentA.S.Loginov Moscow Clinical Scientific Center, Moscow Healthcare DepartmentResearch Institute of PulmonologyA.S.Loginov Moscow Clinical Scientific Center, Moscow Healthcare DepartmentA.S.Loginov Moscow Clinical Scientific Center, Moscow Healthcare DepartmentA.S.Loginov Moscow Clinical Scientific Center, Moscow Healthcare DepartmentA.S.Loginov Moscow Clinical Scientific Center, Moscow Healthcare DepartmentIn order to optimize the therapy, the functional state of the pancreas (P) and the peculiarities of metabolic activity of intestinal microbiota in adults with cystic fibrosis (CF) were assessed. Materials and methods. 14 CF patients (20-34 years, 7 men, 7 women) were enrolled. In 8 patients, the diagnosis was confirmed in the first year of life on the basis of clinical data, positive sweat test, 5 had genetic confirmation. In 4 patients, the diagnosis was confirmed at the age of 8-13 years and 2 patients aged 18, 27 years. In this group, genetic confirmation was in 4 subjects. In addition to general clinical studies, the level of C-peptide in blood, elastase and the concentration of short chain fatty acids in feces was determined. Results and discussion. Of elastase feces in 9 patients was 5.5±4.7 icg/g, that is revealed severe exocrine insufficiency of the pancreas and in 5 patients the elastase level was normal and amounted to 402±124 icg/g. Deployed the clinical picture of diabetes mellitus was observed in 3 patients. Metabolic activity of the colon microflora as a whole was reduced, the sum of the concentration of short-chain fatty acids (ΣCn) was 6.03±4.11 mg/g at a rate of 10.61±5.11 (phttps://ter-arkhiv.ru/0040-3660/article/viewFile/32894/pdfcystic fibrosispancreaselastase of fecesexocrine insufficiencyshort-chain fatty acidsmicrobiota |
| spellingShingle | L V Vinokurova G E Baimakanova S A Krasovsky S Yu Silvestrova E A Dubtsova G G Varvanina D S Bordin Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients Терапевтический архив cystic fibrosis pancreas elastase of feces exocrine insufficiency short-chain fatty acids microbiota |
| title | Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients |
| title_full | Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients |
| title_fullStr | Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients |
| title_full_unstemmed | Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients |
| title_short | Functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients |
| title_sort | functional insufficiency of the pancreas and the metabolic activity of the microbiota in cystic fibrosis adults patients |
| topic | cystic fibrosis pancreas elastase of feces exocrine insufficiency short-chain fatty acids microbiota |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/32894/pdf |
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