Clinical features and biomarkers of semantic variant primary progressive aphasia with MAPT mutation

Clinical features and biomarkers of semantic variant primary progressive aphasia with MAPT mutation

Abstract Background Semantic variant primary progressive aphasia (svPPA) is generally sporadic, with very few reports of tau pathology caused by MAPT mutations. Methods A 64-year-old man was diagnosed with svPPA with MAPT P301L mutation. Clinical information, cognitive and language functions, multim...

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Bibliographic Details
Main Authors: Jing Xu, Yanmin Xia, Meng Meng, Fang Liu, Ping Che, Yanxin Zhang, Ying Wang, Li Cai, Wen Qin, Nan Zhang
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
Frontotemporal lobar degeneration
Semantic variant primary progressive aphasia
MAPT gene
P301L mutation
Next-generation sequencing
Online Access:https://doi.org/10.1186/s13195-023-01176-y

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