Anti-inflammatory effects of Derris scandens extract on narrowband-ultraviolet B exposed HaCaT human keratinocytes
Narrowband-ultraviolet B (NB-UVB) has been used to treat skin diseases such as psoriasis. Chronic use of NB-UVB might cause skin inflammation and lead to skin cancer. In Thailand, Derris Scandens (Roxb.) Benth. is used as an alternative medicine to nonsteroidal anti-inflammatory drugs (NSAIDs) for l...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Journal of Ayurveda and Integrative Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0975947623000086 |
| _version_ | 1797814443823857664 |
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| author | Sumrit Sukhonthasilakun Pramote Mahakunakorn Alisa Naladta Katesaraporn Nuankaew Somsak Nualkaew Chavi Yenjai Natsajee Nualkaew |
| author_facet | Sumrit Sukhonthasilakun Pramote Mahakunakorn Alisa Naladta Katesaraporn Nuankaew Somsak Nualkaew Chavi Yenjai Natsajee Nualkaew |
| author_sort | Sumrit Sukhonthasilakun |
| collection | DOAJ |
| description | Narrowband-ultraviolet B (NB-UVB) has been used to treat skin diseases such as psoriasis. Chronic use of NB-UVB might cause skin inflammation and lead to skin cancer. In Thailand, Derris Scandens (Roxb.) Benth. is used as an alternative medicine to nonsteroidal anti-inflammatory drugs (NSAIDs) for low back pain and osteoarthritis. Therefore, this study aimed to evaluate the potential anti-inflammatory effect of Derris scandens extract (DSE) on pre- and post exposed NB-UVB human keratinocytes (HaCaT). The results indicated that DSE could not protect HaCaT from cell morphology changes or DNA fragmentation and could not recover cell proliferation ability from the NB-UVB effects. DSE treatment reduced the expression of genes related to inflammation, collagen degradation, and carcinogenesis, such as IL-1α, IL-1β, IL-6, iNOS, COX-2, MMP-1, MMP-9, and Bax. These results indicated the potential use of DSE as a topical preparation against NB-UVB-induced inflammation, anti-aging, and prevention of skin cancer from phototherapy. |
| first_indexed | 2024-03-13T08:07:49Z |
| format | Article |
| id | doaj.art-e38adc62c49d4c06b56545b185771f63 |
| institution | Directory Open Access Journal |
| issn | 0975-9476 |
| language | English |
| last_indexed | 2024-03-13T08:07:49Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj.art-e38adc62c49d4c06b56545b185771f632023-06-01T04:35:12ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762023-03-01142100693Anti-inflammatory effects of Derris scandens extract on narrowband-ultraviolet B exposed HaCaT human keratinocytesSumrit Sukhonthasilakun0Pramote Mahakunakorn1Alisa Naladta2Katesaraporn Nuankaew3Somsak Nualkaew4Chavi Yenjai5Natsajee Nualkaew6Division of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Biochemistry, Faculty of Sciences, Khon Kaen University, Khon Kaen 40002, ThailandDivision of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, ThailandPharmaceutical Chemistry and Natural Product Research Unit, Faculty of Pharmacy, Mahasarakham University, Mahasarakham, 44150, ThailandNatural Products Research Unit, Center of Excellence for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, ThailandDivision of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand; Corresponding author.Narrowband-ultraviolet B (NB-UVB) has been used to treat skin diseases such as psoriasis. Chronic use of NB-UVB might cause skin inflammation and lead to skin cancer. In Thailand, Derris Scandens (Roxb.) Benth. is used as an alternative medicine to nonsteroidal anti-inflammatory drugs (NSAIDs) for low back pain and osteoarthritis. Therefore, this study aimed to evaluate the potential anti-inflammatory effect of Derris scandens extract (DSE) on pre- and post exposed NB-UVB human keratinocytes (HaCaT). The results indicated that DSE could not protect HaCaT from cell morphology changes or DNA fragmentation and could not recover cell proliferation ability from the NB-UVB effects. DSE treatment reduced the expression of genes related to inflammation, collagen degradation, and carcinogenesis, such as IL-1α, IL-1β, IL-6, iNOS, COX-2, MMP-1, MMP-9, and Bax. These results indicated the potential use of DSE as a topical preparation against NB-UVB-induced inflammation, anti-aging, and prevention of skin cancer from phototherapy.http://www.sciencedirect.com/science/article/pii/S0975947623000086Derris scandensNarrowband-ultraviolet BHuman keratinocytesUV protectionAnti-inflammationPhototherapy |
| spellingShingle | Sumrit Sukhonthasilakun Pramote Mahakunakorn Alisa Naladta Katesaraporn Nuankaew Somsak Nualkaew Chavi Yenjai Natsajee Nualkaew Anti-inflammatory effects of Derris scandens extract on narrowband-ultraviolet B exposed HaCaT human keratinocytes Journal of Ayurveda and Integrative Medicine Derris scandens Narrowband-ultraviolet B Human keratinocytes UV protection Anti-inflammation Phototherapy |
| title | Anti-inflammatory effects of Derris scandens extract on narrowband-ultraviolet B exposed HaCaT human keratinocytes |
| title_full | Anti-inflammatory effects of Derris scandens extract on narrowband-ultraviolet B exposed HaCaT human keratinocytes |
| title_fullStr | Anti-inflammatory effects of Derris scandens extract on narrowband-ultraviolet B exposed HaCaT human keratinocytes |
| title_full_unstemmed | Anti-inflammatory effects of Derris scandens extract on narrowband-ultraviolet B exposed HaCaT human keratinocytes |
| title_short | Anti-inflammatory effects of Derris scandens extract on narrowband-ultraviolet B exposed HaCaT human keratinocytes |
| title_sort | anti inflammatory effects of derris scandens extract on narrowband ultraviolet b exposed hacat human keratinocytes |
| topic | Derris scandens Narrowband-ultraviolet B Human keratinocytes UV protection Anti-inflammation Phototherapy |
| url | http://www.sciencedirect.com/science/article/pii/S0975947623000086 |
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